HYDROXYLATION OF ALKYL GROUPS ON THE PYRAZINE RING
Treatment of THF solutions of 2,5-dialkylpyrazine 1-oxides with oxygen in the presence of bases gave the corresponding 2-hydroxypyrazine 1-oxides and dimers.On the other hand, when 2-chloro-3,6-dialkylpyrazine 1-oxides and 3,6-dialkyl-2-hydroxypyrazine 1-oxides were treated under the same conditions, hydroxylation occurred successfully at the α-position of the side chain.
Ohta, Akihiro,Ohta, Minoru
p. 151 - 154
(2007/10/02)
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