813433-76-0

Basic information

• Product Name: (S)-N-Boc-Morpholine-3-acetic acid
• Synonyms: (S)-N-Boc-3-(2-hydroxyethyl)morpholine;(S)-4-Boc-3-(2-hydroxyethyl)morpholine;(3S)-3-(2-Hydroxyethyl)-4-morpholinecarboxylic acid tert-butyl ester;(S)-tert-Butyl 3-(2-hydroxyethyl)morpholine-4-carboxylate;morpholine-4-carboxylate;-tert-Butyl 3-(2-hydroxyethyl);(S)-N-Boc-Morpholine-3-acetic acid
• CAS NO: 813433-76-0
• Molecular Formula: C11H21NO4
• Molecular Weight: 231.29
• Mol File: 813433-76-0.mol

Chemical Properties

• Boiling Point: 336℃
• Flash Point: 157℃
• Appearance: /
• Density: 1.097
• Vapor Pressure: 8.15E-06mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-N-Boc-Morpholine-3-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-Boc-Morpholine-3-acetic acid(813433-76-0)
• EPA Substance Registry System: (S)-N-Boc-Morpholine-3-acetic acid(813433-76-0)

Safety Data

• Hazardous Substances Data: 813433-76-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(S)-N-Boc-Morpholine-3-acetic acid is used as a protecting agent for amines in organic synthesis processes. The Boc group's ability to protect amines is crucial for preventing unwanted side reactions during the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the pharmaceutical industry, (S)-N-Boc-Morpholine-3-acetic acid is used as a building block for the development of new drugs. The morpholine ring's capacity to increase the bioavailability of pharmaceutical drugs makes it an essential component in the design and synthesis of more effective medications.
Used in Laboratory Research:
(S)-N-Boc-Morpholine-3-acetic acid is employed as a reagent in various laboratory experiments and chemical reactions. Its versatility in organic synthesis and potential applications in medicinal chemistry make it a valuable tool for researchers working on the development of new chemical compounds and drug candidates.
Used in Industrial Chemical Reactions:
(S)-N-Boc-Morpholine-3-acetic acid is utilized in industrial settings for the production of complex organic molecules and pharmaceutical drugs. Its role in protecting amines and enhancing the bioavailability of drugs makes it a key component in the synthesis of a wide range of chemical products.

InChI:InChI=1/C11H21NO4/c1-11(2,3)16-10(14)12-5-7-15-8-9(12)4-6-13/h9,13H,4-8H2,1-3H3/t9-/m0/s1

Upstream product

• 1000806-54-1 (E)-(4-tert-butoxycarbonylaminoethoxy)-2-butenal 
• 813433-72-6 (4-formyl-morpholin-3-yl)-acetic acid 
• 86236-84-2 2-(morpholin-3-yl)acetic acid 
• 81684-84-6 ethyl 2-(morpholin-3-yl)acetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 761460-04-2 (3S)-4-tert-butoxycarbonyl-3-carbethoxymethylmorpholine 
• 761460-02-0 tert-Butyl 3-(2-ethoxy-2-oxoethyl)morpholine-4-carboxylate 

Relevant articles and documents

NOVEL IMIDAZOLE COMPOUND AND USE THEREOF AS MELANOCORTIN RECEPTOR AGONIST

The present invention relates to a novel imidazole compound or a pharmaceutically acceptable salt thereof having a melanocortin receptor agonistic activity, and medical use thereof. The present invention relates to an imidazole compound represented by general formula [I] [wherein: Ring A represents an optionally substituted aryl group or the like; R1 represents a hydrogen atom, an optionally substituted alkyl group, or the like; R2 represents a hydrogen atom, a halogen atom, or the like; and R3 represents an optionally substituted alkyl group] or a pharmaceutically acceptable salt thereof.

Pharmaceutical compositions (by machine translation)

[Problem] imidazole compound or its pharmacologically acceptable salt in the melanocortin receptor activity that operates as an active ingredient of a pharmaceutical composition comprising. "I" general formula [a]" Formula, the aryl group may be substituted A ring represents a; R1 Represents a hydrogen atom, or an alkyl group which may be substituted represented; R2 Represents a hydrogen atom, a halogen atom or represents a; R3 The alkyl group may be substituted " represented by the imidazole compound, its pharmacologically acceptable salt as an active ingredient in a pharmaceutical composition. [Drawing] no (by machine translation)

Enantioselective organocatalytic intramolecular aza-Michael reaction: A concise synthesis of (+)-sedamine, (+)-allosedamine, and (+)-coniine

(Chemical Equation Presented) The intramolecular aza-Michael reaction of carbamates bearing remote α,β-unsaturated aldehydes under organocatalytic conditions took place with good yields and excellent ee's when Jorgensen catalyst IV was used in the process, giving rise to the enantioselective formation of several five- and six-membered heterocycles. The developed methodology was applied to the synthesis of three piperidine alkaloids.

Enzymatic resolution of cyclic N-Boc protected β-aminoacids

Methyl and ethyl esters of N-Boc homoproline, homopipecolic acid and 3-carboxymethyl-morpholine were kinetically resolved by hydrolysis catalysed by Burkholderia cepacia lipase to give the corresponding acids and residual esters in enantiomeric excesses better than 99% (E > 100).

An efficient synthesis of chiral cyclic β-amino acids via asymmetric hydrogenation

Cyclic β-amino acids, homoproline, homopipecolic acid and 3-carboxy-methylmorpholine were obtained in high enantiomeric excesses by transition metal-catalyzed asymmetric hydrogenation of cyclic β-acylamino-alkenoates. These compounds were synthesized by a