816457-58-6

Basic information

• Product Name: Potassium 3-(trifluoromethyl)phenyltrifluoroborate
• Synonyms: Potassium 3-(trifluoromethyl)phenyltrifluoroborate;potassium:trifluoro-[3-(trifluoromethyl)phenyl]boranuide
• CAS NO: 816457-58-6
• Molecular Formula: C7H4BF6K
• Molecular Weight: 252.0063792
• Mol File: 816457-58-6.mol

Chemical Properties

• Melting Point: 228.2-230.7°C
• Appearance: /
• CAS DataBase Reference: Potassium 3-(trifluoromethyl)phenyltrifluoroborate(CAS DataBase Reference)
• NIST Chemistry Reference: Potassium 3-(trifluoromethyl)phenyltrifluoroborate(816457-58-6)
• EPA Substance Registry System: Potassium 3-(trifluoromethyl)phenyltrifluoroborate(816457-58-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 816457-58-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Potassium 3-(trifluoromethyl)phenyltrifluoroborate is used as a reagent for the preparation of chiral amino phospho acids or their derivatives. This is achieved through a one-pot 1,4-addition/diastereoselective protonation process, involving an organometallic compound, a transition metal catalyst, and a chiral ligand. The resulting chiral amino phospho acids and their derivatives are valuable building blocks in the synthesis of pharmaceuticals and agrochemicals, as they can exhibit biological activity and selectivity.
Used in Organic Synthesis:
In the field of organic synthesis, Potassium 3-(trifluoromethyl)phenyltrifluoroborate serves as a useful reagent for the introduction of the trifluoromethyl group onto aromatic rings. This can lead to the formation of various trifluoromethylated compounds with potential applications in materials science, agrochemicals, and pharmaceuticals. The trifluoromethyl group is known to enhance the lipophilicity, metabolic stability, and biological activity of molecules, making it an attractive modification for drug design.