- PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT AND PREVENTION OF ORTHOPOXVIRUS INFECTIONS AND ASSOCIATED DISEASES
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Pharmaceutical compositions containing di, tri, and tetracyclic acylhydrazide derivatives of the formula below, for use in the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.
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- METHODS OF PREPARING TECOVIRIMAT
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Disclosed are methods for the preparation of Tecovirimat for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.
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- Polymorphic Forms of ST-246 and Methods of Preparation
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Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
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Page/Page column 12-14
(2011/10/12)
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- N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f] isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors
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A series of novel, potent orthopoxvirus egress inhibitors was identified during high-throughput screening of the ViroPharma small molecule collection. Using structure-activity relationship information inferred from early hits, several compounds were synth
- Bailey, Thomas R.,Rippin, Susan R.,Opsitnick, Elizabeth,Burns, Christopher J.,Pevear, Daniel C.,Collett, Marc S.,Rhodes, Gerry,Tohan, Sanjeev,Huggins, John W.,Baker, Robert O.,Kern, Earl R.,Keith, Kathy A.,Dai, Dongcheng,Yang, Guang,Hruby, Dennis,Jordan, Robert
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p. 1442 - 1444
(2007/10/03)
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