Caprolactams as potent CGRP receptor antagonists for the treatment of migraine
Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Replacements for the benzodiazepine core of an earlier lead structure 1 including 5-, 6-, and 7-membered lactams were explored. Within the 7-membered ring scaffold
Shaw, Anthony W.,Paone, Daniel V.,Nguyen, Diem N.,Stump, Craig A.,Burgey, Christopher S.,Mosser, Scott D.,Salvatore, Christopher A.,Rutledge, Ruth Z.,Kane, Stefanie A.,Koblan, Kenneth S.,Graham, Samuel L.,Vacca, Joeseph P.,Williams, Theresa M.
p. 4795 - 4798
(2008/03/14)
LACTAMS AND BICYCLIC LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS
This invention relates to lactams, bicyclic lactams and related compounds which are useful as cholecystokinin antagonists.
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(2008/06/13)
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