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4-CBZ-3(S)-MORPHOLINECARBOXYLIC ACID is a chiral morpholinecarboxylic acid derivative, characterized by a carbobenzyloxy (CBZ) group and a 3(S) stereoisomer. It serves as a crucial intermediate in the synthesis of pharmaceuticals, with its unique structure and properties making it valuable in the pharmaceutical industry.

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  • 819078-65-4 Structure
  • Basic information

    1. Product Name: 4-CBZ-3(S)-MORPHOLINECARBOXYLIC ACID
    2. Synonyms: 4-CBZ-3(S)-MORPHOLINECARBOXYLIC ACID;(S)-4-CBZ-MORPHOLINE-3-CARBOXYLIC ACID;(3S)-4-Cbz-3,4-Morpholinedicarboxylic acid;(3S)-3,4-Morpholinedicarboxylic Acid 4-(Phenylmethyl) Ester;(3S)-4-benzyloxycarbonylmorpholine-3-carboxylic acid
    3. CAS NO:819078-65-4
    4. Molecular Formula: C13H15NO5
    5. Molecular Weight: 265.26
    6. EINECS: N/A
    7. Product Categories: pharmacetical
    8. Mol File: 819078-65-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 464.3°C at 760 mmHg
    3. Flash Point: 234.6°C
    4. Appearance: /
    5. Density: 1.332g/cm3
    6. Vapor Pressure: 2.03E-09mmHg at 25°C
    7. Refractive Index: 1.568
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 3.51±0.20(Predicted)
    11. CAS DataBase Reference: 4-CBZ-3(S)-MORPHOLINECARBOXYLIC ACID(CAS DataBase Reference)
    12. NIST Chemistry Reference: 4-CBZ-3(S)-MORPHOLINECARBOXYLIC ACID(819078-65-4)
    13. EPA Substance Registry System: 4-CBZ-3(S)-MORPHOLINECARBOXYLIC ACID(819078-65-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 819078-65-4(Hazardous Substances Data)

819078-65-4 Usage

Uses

Used in Pharmaceutical Industry:
4-CBZ-3(S)-MORPHOLINECARBOXYLIC ACID is used as a key intermediate for the synthesis of various drugs and biologically active compounds. Its chiral center at the 3-position allows for the creation of stereospecific pharmaceuticals, which can have different biological activities and selectivity.
Used in Drug Development:
4-CBZ-3(S)-MORPHOLINECARBOXYLIC ACID is utilized as a precursor in the development of new drugs, particularly in the synthesis of chiral compounds. Its unique structure enables the production of enantiomerically pure compounds, which can have improved therapeutic effects and reduced side effects compared to their racemic counterparts.
Used in Medicinal Chemistry Research:
4-CBZ-3(S)-MORPHOLINECARBOXYLIC ACID is employed as a building block in medicinal chemistry research, allowing scientists to explore its potential applications in the design and synthesis of novel therapeutic agents. Its versatile chemical properties make it a promising candidate for the development of new drugs with improved pharmacological profiles.
Used in Chiral Synthesis:
4-CBZ-3(S)-MORPHOLINECARBOXYLIC ACID is used as a chiral synthon in asymmetric synthesis, enabling the preparation of enantiomerically pure compounds with high selectivity. Its 3(S) stereochemistry can be exploited to control the stereochemical outcome of various chemical reactions, leading to the formation of biologically active compounds with desired chiralities.

Check Digit Verification of cas no

The CAS Registry Mumber 819078-65-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,9,0,7 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 819078-65:
(8*8)+(7*1)+(6*9)+(5*0)+(4*7)+(3*8)+(2*6)+(1*5)=194
194 % 10 = 4
So 819078-65-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H15NO5/c15-12(16)11-9-18-7-6-14(11)13(17)19-8-10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H,15,16)/t11-/m0/s1

819078-65-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-4-Cbz-Morpholine-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names (3S)-4-phenylmethoxycarbonylmorpholine-3-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:819078-65-4 SDS

819078-65-4Downstream Products

819078-65-4Relevant articles and documents

HEXAHYDROOXAZINOPTERINE COMPOUNDS

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Page/Page column 14, (2011/04/14)

The present invention provides mTOR inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods of making the compounds and intermediates thereof; and methods of using the compounds.

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