Aminolysis of isatin and N-acetyl isatin in acetonitrile and mixed acetonitrile-water solvents
The reactions of N-acetyl isatin and N-propionyl isatin with morpholine, piperazine and diethylamine in acetonitrile underwent nucleophilic substitution reactions at the amide linkage with ring opening process to give N-[2-(2-amino-2-oxo-acetyl)phenyl]ace