- REMEDY FOR DIABETES
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A method of screening a compound having a hypoglycemic effect (hereinafter referred to as "hypoglycemic compound"), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
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Page/Page column 22
(2010/04/23)
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- Cyclopentenone Derivatives, V. Stereoselective Cyclopentanone Anellations
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1,3 or 1,4 located donating centers in additions to 4-acetoxy-2-cyclopenten-1-one (1) stereoselectively give rise to cyclic cis anellation products (5, 13, 16, 20 - 22) which depending on substituents may be opened to cis disubstituted cyclopentanone derivatives (5 -> 10).Starting with the 1,5 located donor 19d corresponding trans hydroazulene derivative (23) is formed.This way an intermediate for a simple total synthesis of vetivazulene (29) is obtained.
- Harre, Michael,Winterfeldt, Ekkehard
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p. 1437 - 1447
(2007/10/02)
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