- Synthesis and antibacterial activity of some 4-(coumarin-3-yl)/Aryl 2 (3,5-dimethylpyrazol-1-yl)thiazoles
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Reaction of 3-(2-bromoacetyl) coumarins (4) with 3,5-dimethylpyrazol-1- thiocarboxamide (5) results in the formation of title compounds 6. 4-Aryl-2-(3,5-dimethylpyrazol-1-yl) thiazoles (8) which could not be synthesized earlier through this method, were obtained by performing the reaction in presence of a base. All the synthesized compounds have shown moderate to significant antibacterial activity against Gram-positive bacteria namely S. aureus and B. subtilis.
- Aggarwal, Ranjana,Kumar, Sunil,Sharma, Chetan,Aneja, Kamal R.,Singh, Shiv P.
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p. 331 - 336
(2013/09/24)
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- β,β-Dibromoketones: A superior alternative to β-bromoketones in hantzsch thiazole synthesis
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β,β-Dibromoketones (2) have been found to be a superior alternative to the conventionally used β-bromoketones (1) for performing the Hantzsch thiazole synthesis.1 These crystalline, nonlachrymatory compounds are more reactive than 1 as demonstrated by the
- Prakash, Richa,Kumar, Ajay,Aggarwal, Ranjana,Prakash, Om,Singh
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p. 2501 - 2505
(2008/02/10)
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- Synthesis and Mass Spectral Studies of Some 2-(3',5'-Dimethylpyrazol-1'-yl)-4-arylthiazoles and Their 4'-Alkyl/Carboxymethyl Analogues
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A number of 2-(3',5'-dimethylpyrazol-1'-yl)-4-arylthiazoles (IIa, d, g, j) and their 4'-alkyl (IIb, c, e, f, h, i, k, l) and 4'-carbethoxymethyl (III) analogues have been synthesized by the condensation of appropriate 2-hydrazino-4-arylthiazoles (I) with pentane-2,4-dione and its 3-substituted analogues.Alkaline hydrolysis of III gives the corresponding acids (IVa-d).The mass spectral studies reveal that the major fragmentation of II involves decomposition of pyrazole ring with the expulsion of methyl cyanide, fission of thiazole ring and the loss of methyl groupfrom the molecular ion.These and the other competing processes which involve skeletal rearrangement in the pyrazole moiety have been supported by the high resolution measurements.Presence of ethoxycarbonyl (III) or a carboxy function (IV), however, triggers an alternative low-energy pathway involving the preferential expulsion of these groups from the molecular ion prior to the decomposition of either of the heterocyclic moieties.The compounds have been screened for their antiinflammatory activity.
- Singh, S. P.,Kodali, Dharma R.,Dhindsa, G. S.,Sawhney, S. N.
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