Synthesis, bioassay, and molecular field topology analysis of diverse vasodilatory heterocycles
A diverse training set composed of 76 in-house synthesized and 61 collected from the literature was subjected to molecular field topology analysis. This resulted in a high-quality quantitative structure-activity relationships model (R2 = 0.932,
Oliferenko, Polina V.,Oliferenko, Alexander A.,Girgis, Adel S.,Saleh, Dalia O.,Srour, Aladdin M.,George, Riham F.,Pillai, Girinath G.,Panda, Chandramukhi S.,Hall, C. Dennis,Katritzky, Alan R.
p. 1103 - 1116
(2014/05/20)
CYCLIZATION REACTIONS OF NITRILES. 2-ARYL-3-(2-THENOYL)-1,1-DICYANOPROPANES AND PYRIDINE DERIVATIVES BASED ON THEM
In the reaction of 1,1,1-trifluoro-3-(2-thenoyl)acetone with arylidenemalononitriles acid cleavage of the products from Michael addition takes place with the formation of 2-aryl-3-(2-thenoyl)-1,1-dicyanopropanes.They were used for the synthesis of 4-aryl-2-bromo-6-(2-thienyl)-3-cyanopyridines and 4-aryl-6-(2-thienyl)-3-cyano-2(1H)-pyridinethiones and condensed heterocyclic compounds based on them.
Sharanin, Yu. A.,Promonenkov, V. K.,Shestopalov, A. M.
p. 548 - 556
(2007/10/02)
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