Synthesis and evaluation of heteroaryl-ketone derivatives as a novel class of VEGFR-2 inhibitors
We have discovered novel inhibitors of VEGFR-2 kinase with low nanomolar potency in both enzymatic and cell-based assays. Active series are heteroaryl-ketone compounds containing a central aromatic ring with either an indazolyl or indolyl keto group in th
Piatnitski Chekler, Eugene L.,Katoch-Rouse, Reeti,Kiselyov, Alexander S.,Sherman, Dan,Ouyang, Xiaohu,Kim, Ki,Wang, Ying,Hadari, Yaron R.,Doody, Jacqueline F.
supporting information; experimental part
p. 4344 - 4347
(2009/04/06)
HETEROARYLAMINO-PHENYLKETONE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS
The present invention relates to compounds that inhibit VEGF receptor tyrosine kinases, especially KDR, pharmaceutical compositions that contain such compounds, methods of treating VEGF receptor kinase-dependent diseases and conditions in mammals using such compounds and composition and methods for their manufacture.
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Page 38
(2010/02/10)
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