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82189-04-6

Mycotrienin II, also known as Ansatrienin B and Antibiotic T 23II, is a novel class of ansamycins that inhibits osteoclastic bone resorption, potentiates the activity of several clinically useful antitumor agents, and prevents ICAM-1 expression induced by pro-inflammatory cytokines.

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  • 82189-04-6 Structure

  • Basic information

    1. Product Name: mycotrienin II
    2. Synonyms: mycotrienin II;20,23-Didehydro-20,23-dideoxo-20,23-dihydroxyansatrienol A 11-[(R)-2-(cyclohexylcarbonylamino)propanoate];T 23II, Mycotrienin II, T 23II
    3. CAS NO:82189-04-6
    4. Molecular Formula: C36H50N2O8
    5. Molecular Weight: 638.797
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 82189-04-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 834.5°C at 760 mmHg
    3. Flash Point: 458.5°C
    4. Appearance: /
    5. Density: 1.21g/cm3
    6. Vapor Pressure: 1.54E-29mmHg at 25°C
    7. Refractive Index: 1.588
    8. Storage Temp.: -20°C
    9. Solubility: Soluble in DMSO, DMF, Ethanol or Methanol
    10. Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol, or methanol may be stored at -20°C for up to 3 months.
    11. CAS DataBase Reference: mycotrienin II(CAS DataBase Reference)
    12. NIST Chemistry Reference: mycotrienin II(82189-04-6)
    13. EPA Substance Registry System: mycotrienin II(82189-04-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 82189-04-6(Hazardous Substances Data)

82189-04-6 Usage

Uses

Used in Pharmaceutical Industry:
Mycotrienin II is used as an antitumor agent for its potent activity against tumor cell lines and its ability to inhibit osteoclastic bone resorption. It also significantly potentiates the action of several clinical anti-cancer agents, making it a valuable compound in the development of cancer treatments.
Used in Orthopedic Applications:
Mycotrienin II is used as a bone resorption inhibitor to prevent the breakdown of bone tissue, which can be particularly useful in the treatment of osteoporosis and other bone-related conditions.
Used in Inflammation Management:
Mycotrienin II is used as an anti-inflammatory agent for its ability to prevent ICAM-1 expression induced by pro-inflammatory cytokines, which can help in managing inflammatory conditions and reducing the associated symptoms.

References

1) Sugita et al. (1982), Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II; J. Antibiot. (Tokyo), 35 1467 2) Feuerbach et al. (1995), Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption; J. Biol. Chem., 270 25949 3) Yamada et al. (2011), Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines; J. Antibiot. (Tokyo), 64 361

Check Digit Verification of cas no

The CAS Registry Mumber 82189-04-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,1,8 and 9 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 82189-04:
(7*8)+(6*2)+(5*1)+(4*8)+(3*9)+(2*0)+(1*4)=136
136 % 10 = 6
So 82189-04-6 is a valid CAS Registry Number.
InChI:InChI=1/C36H50N2O8/c1-23-14-13-17-27-20-28(39)21-30(34(27)42)38-32(40)22-29(45-4)18-11-6-5-7-12-19-31(24(2)33(23)41)46-36(44)25(3)37-35(43)26-15-9-8-10-16-26/h5-7,11-12,14,18,20-21,24-26,29,31,33,39,41-42H,8-10,13,15-17,19,22H2,1-4H3,(H,37,43)(H,38,40)/b6-5+,12-7+,18-11+,23-14+/t24-,25-,29+,31+,33+/m1/s1

82189-04-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name [(4E,6R,7S,8S,10E,12E,14E,16R)-6,22,24-trihydroxy-16-methoxy-5,7-dimethyl-18-oxo-19-azabicyclo[18.3.1]tetracosa-1(23),4,10,12,14,20(24),21-heptaen-8-yl] (2R)-2-(cyclohexanecarbonylamino)propanoate

1.2 Other means of identification

Product number -
Other names Mycotrienin II

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:82189-04-6 SDS

82189-04-6Relevant articles and documents

(+)-Mycotrienins I and II: Relative and absolute stereochemistry

Smith III,Wood,Omura

, p. 841 - 842 (2007/10/02)

The complete relative and absolute stereochemistry of the potent antifungal antibiotics (+)-mycotrienin I and (+)-mycotrienin II have been established by chemical correlation with the antitumor agent (+)-trienomycin A.

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