C-C - CONNECTIVE SYNTHESIS OF α-DIALKYLAMINO - KETONES FROM ALDEHYDES AND SEC.-AMINES
A simple and efficient 3 - step synthesis of α-dialkylamino - ketones 3 starting from aldehydes and sec.-amines is described.The unsymmetrically aminoketones are obtained as pure regioisomers via reaction of metalated α-aminonitriles 1 with aldehydes, followed by thermal HCN-elimination/tautomerization.
Enders, Dieter,Lotter, Hermann
p. 639 - 642
(2007/10/02)
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