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m-PEG9-Tos is a PEG (polyethylene glycol) linker that incorporates a tosyl group, which serves as an excellent leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer enhances solubility in aqueous media, making it a versatile component in various applications.

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  • 82217-01-4 Structure
  • Basic information

    1. Product Name: m-PEG9-Tos
    2. Synonyms: m-PEG9-Tos
    3. CAS NO:82217-01-4
    4. Molecular Formula: C24H42O11S
    5. Molecular Weight: 538.64868
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 82217-01-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: m-PEG9-Tos(CAS DataBase Reference)
    10. NIST Chemistry Reference: m-PEG9-Tos(82217-01-4)
    11. EPA Substance Registry System: m-PEG9-Tos(82217-01-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 82217-01-4(Hazardous Substances Data)

82217-01-4 Usage

Uses

Used in Bioconjugation:
m-PEG9-Tos is used as a bioconjugation agent for attaching biomolecules to other entities, such as nanoparticles or other molecules. The tosyl group facilitates the coupling process through nucleophilic substitution, while the PEG spacer improves solubility and stability.
Used in Drug Delivery Systems:
In the pharmaceutical industry, m-PEG9-Tos is used as a component in drug delivery systems to improve the solubility and bioavailability of therapeutic agents. The PEG spacer can help reduce immunogenicity and increase the circulation time of drug carriers in the body.
Used in Polymer Science:
m-PEG9-Tos is utilized as a building block in the synthesis of functional polymers. The tosyl group allows for further modification and branching, while the PEG segment contributes to the overall properties of the polymer, such as its hydrophilicity and biocompatibility.
Used in Chemical Synthesis:
In organic synthesis, m-PEG9-Tos serves as an intermediate or protecting group, taking advantage of the tosyl group's reactivity in nucleophilic substitution reactions. This allows for the selective modification of molecules and the introduction of PEG-based functionalities.

Check Digit Verification of cas no

The CAS Registry Mumber 82217-01-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,2,1 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 82217-01:
(7*8)+(6*2)+(5*2)+(4*1)+(3*7)+(2*0)+(1*1)=104
104 % 10 = 4
So 82217-01-4 is a valid CAS Registry Number.

82217-01-4Relevant articles and documents

Synthesis and photophysical characterization of highly water-soluble PEGylated BODIPY derivatives for cellular imaging

Badon, Isabel Wen,Lee, Joomin,Pegarro Vales, Temmy,Cho, Byoung Ki,Kim, Ho-Joong

, p. 214 - 219 (2019)

A series of poly(ethylene glycol) (PEG)-modified water-soluble boron dipyrromethene (BODIPY) dyes (EtBOD-PEG and BOD-PEG) were synthesized and their photophysical properties in various solutions were investigated. The presence of ethyl groups at the 2,6-p

CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS

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Page/Page column 169, (2021/10/30)

Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.

A CONJUGATE OF A CYTOTOXIC AGENT TO A CELL BINDING MOLECULE WITH BRANCHED LINKERS

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Page/Page column 226; 271, (2021/01/23)

Provided is a conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.

A CONJUGATE OF AN AMANITA TOXIN WITH BRANCHED LINKERS

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Page/Page column 163, (2020/08/22)

Provided herein is the conjugation of an amanita toxin compound to a cell-binding molecule with branched linkers for having better targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of an amanita molecule to a cell-binding ligand, as well as methods of using the conjugate in targets treatment of cancer, infection and autoimmune disease.

Visible-Light-Induced Cysteine-Specific Bioconjugation: Biocompatible Thiol–Ene Click Chemistry

Choi, Hangyeol,Hong, Sungwoo,Jang, Jaebong,Kim, Myojeong

supporting information, p. 22514 - 22522 (2020/10/15)

Bioconjugation methods using visible-light photocatalysis have emerged as powerful synthetic tools for the selective modification of biomolecules under mild reaction conditions. However, the number of photochemical transformations that allow successful protein bioconjugation is still limited because of the need for stringent reaction conditions. Herein, we report that a newly developed water-compatible fluorescent photosensitizer QPEG can be used for visible-light-induced cysteine-specific bioconjugation for the installation of QPEG by exploiting its intrinsic photosensitizing ability to activate the S?H bond of cysteine. The slightly modified QCAT enables the effective photocatalytic cysteine-specific conjugation of biologically relevant groups. The superior reactivity and cysteine selectivity of this methodology was further corroborated by traceless bioconjugation with a series of complex peptides and proteins under biocompatible conditions.

A silibinin ether derivatives and its synthetic method and application

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Paragraph 014-0150, (2018/05/24)

The invention discloses a derivative of silybin ethers, and a synthetic method and application thereof. The derivative of the silybin ethers has a structural formula as shown in a formula I, wherein R1 is a -(CH2CH2O)mR4 group; R2 is hydrogen or the -(CH2

Complex compound

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Paragraph 0042; 0043, (2016/10/10)

PROBLEM TO BE SOLVED: To provide a new complex compound that can be used as a catalyst for an organic synthesis reaction and in particular a surfactant type catalyst having both functions of catalytic ability and surface active ability. SOLUTION: A complex compound comprises a nitrogen-containing heterocyclic carbene ligand represented by formula (A) and including at least one metal atom selected from palladium, silver, rhodium, iridium, and ruthenium as a central metal. (R1 represents a divalent hydrocarbon group that has 2-20 carbon atoms and may include at least one atom selected from N, O, S and halogen atoms; R2 represents a hydrocarbon group having 6-70 carbon atoms and including a polyoxyalkylene group and/or a polyglyceryl group having a polymerization number of 2-20 or a hydrocarbon group having 2-20 carbon atoms and including at least one ionic functional group selected from a sulfonic acid group, a carboxyl group, an ammonium group, or their salts; and R3 represents a hydrocarbon group having 2-20 carbon atoms) SELECTED DRAWING: None COPYRIGHT: (C)2016,JPO&INPIT

Antioxidants Having Aromatic Structures Reacting with Superoxide

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Sheet 4, (2016/07/27)

Disclosed is a method of treating diseases which are: reactive oxygen species mediated, ischemic or reperfusion-related, or T-cell mediated, including autoimmune diseases. The method is administering a therapeutically effective amount of a formulation wherein the active ingredient includes non-phenolic aromatic structures that are electron deficient and are capable of converting the superoxide radical to O2; and/or of converting superoxide radical to oxygen and hydrogen peroxide, or pharmaceutically acceptable salts of said structures. Also disclosed is a method of diagnosing and treating such diseases and conditions.

New guests for the cucurbit[8]uril host. Formation of G2H ternary complexes

Senler, Sanem,Cui, Lu,Broomes, Ana Michelle,Smith, Erika L.,Wilson, James N.,Kaifer, Angel E.

experimental part, p. 592 - 596 (2012/08/28)

On the basis of the highly stable G2H (2:1) ternary complex formed by two methyl viologen cation radicals inside the cavity of cucurbit[8]uril, we prepared three monocationic 4-phenylpyridinium derivatives: 1-(hydroxyethyl)-4-phenyl-pyridinium

TREATMENT OF MYOPIA

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Page/Page column 31, (2010/02/14)

The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment and/or prevention of myopia. An activating energy source is utilize

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