823221-97-2

Basic information

• Product Name: 3-bromo-5-chloro-2-iodopyridine
• Synonyms: 3-bromo-5-chloro-2-iodopyridine
• CAS NO: 823221-97-2
• Molecular Formula: C₅H₂BrClIN
• Molecular Weight: 318.33755
• Mol File: 823221-97-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-bromo-5-chloro-2-iodopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-5-chloro-2-iodopyridine(823221-97-2)
• EPA Substance Registry System: 3-bromo-5-chloro-2-iodopyridine(823221-97-2)

Safety Data

• Hazardous Substances Data: 823221-97-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
3-bromo-5-chloro-2-iodopyridine is used as a key intermediate for the synthesis of biologically active compounds, playing a crucial role in the development of new pharmaceuticals. Its unique reactivity allows for the creation of a variety of drug candidates with potential therapeutic applications.
Used in Agrochemical Research:
In the agrochemical industry, 3-bromo-5-chloro-2-iodopyridine is employed as a building block for the synthesis of novel agrochemicals. Its potential to form a range of chemical entities makes it instrumental in the development of new pesticides, herbicides, and other agricultural chemicals designed to improve crop yields and protect against pests.
Used in Organic Synthesis:
3-bromo-5-chloro-2-iodopyridine is utilized as a versatile reactant in organic synthesis, enabling the formation of complex molecules with diverse applications. Its presence in synthetic pathways can lead to the production of specialty chemicals, advanced materials, and other compounds of interest in various industries.

Upstream product

• 137628-17-2 2,3-dibromo-5-chloro-pyridine 
• 26163-03-1 2-amino-3-bromo-5-chloropyridine 

Downstream Products

• 823222-22-6 3-bromo-5-chloro-2-(trifluoromethyl)pyridine 
• 823222-02-2 5-chloro-2-(trifluoromethyl)pyridine-3-carboxylic acid 

Relevant articles and documents

Preparation process of 2-iodo-3-bromo-5-chloropyridine

The invention discloses a preparation process of 2-iodo-3-bromo-5-chloropyridine, wherein with 2-amino-3-bromo-5-chloropyridine is employed as a raw material and is subjected to a one-step reaction to synthesize the target product 2-iodo-3-bromo-5-chloropyridine, total yield reaching 71.2%. The preparation process employs low-cost and easy-to-obtained raw materials, has mild and easy-to-control reaction conditions, simple and convenient after treatment and high yield, and is easy to industrially apply.

Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids

Although there are many conceivable ways to funtionalize, and specifically carboxylate, 2-chloro-4-(trifluoromethyl)pyridine optionally at all three vacant positions, it is more straightforward to prepare only the 2-chloro-4- (trifluoromethyl)pyridine-3-carboxylic acid (1) from this precursor and the other 6-chloro-4-(trifluoromethyl)pyridine-2- and -3-carboxylic acids (2 and 3) from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl)pyridine. In the same manner, it proved more convenient to convert 5-chloro-2-(trifluoromethyl) pyridine in only two of the corresponding acids (6 and 7) and to make the third one (8) from 3-bromo-5-chloro-2-(trifluoromethyl)pyridine as an alternative starting material. All model substrates for functionalization were readily accessible from the correspondingly substituted chloroiodopyridine through heavy halogen displacement by in situ generated (trifluoromethyl)copper. Graphical Abstract