- On the Gold-Catalyzed Generation of Vinyl Cations from 1,5-Diynes
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Conjugated 1,5-diynes bearing two aromatic units at the alkyne termini were converted in the presence of a gold catalyst. Under mild conditions, aryl-substituted dibenzopentalenes were generated. Calculations predict that aurated vinyl cations are key intermediates of the reaction. A bidirectional approach provided selective access to the angular annulated product in high yield, which was explained by calculations.
- Wurm, Thomas,Bucher, Janina,Duckworth, Sarah B.,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.
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supporting information
p. 3364 - 3368
(2017/03/17)
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- Cytotoxicities, cell cycle and caspase evaluations of 1,6-diaryl-3(Z)- hexen-1,5-diynes, 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines and their derivatives
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Compounds 3, 6-7, 9-10, 15-17, and 20-21 showed growth inhibition effects on a full panel of 60 human cancer cell lines, and most of the average IC 50 values of the indicated analogues were from 0.01 to 96.6 μM, in which analogues 16 and 17 re
- Lin, Chi-Fong,Lo, Yu-Hsiang,Hsieh, Ming-Chu,Chen, Yi-Hua,Wang, Jeh-Jeng,Wu, Ming-Jung
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p. 3565 - 3575
(2007/10/03)
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