Design, synthesis and biological activities of dihydroaurones
To widen aurones applicability in achromatic food and cosmetic applications, a series of dihydroaurones were designed to mimic natural aurones as well as synthetic aurones. Dihydroaurones have been synthesized from the corresponding aurones by hydrogenation. These dihydroaurones and their corresponding aurones were screened for antioxidant, anti-inflammatory and tyrosinase enzyme inhibitory activity. Synthesized dihydroaurones (3b-f) displayed superior antioxidant activity in superoxide free radical scavenging assay than the standard gallic acid. Dihydroaurones (3b-f) also exhibited significant tyrosinase enzyme inhibitory activity and two dihydroaurones (3h, 3j) showed promising 5-lipoxygenase inhibitory activity.
Neoraufuracin and Ambofuracin. Two Novel 2-Benzyl-2-O-(methyl-β-D-glucopyranos-2-yl)-trans-2,3-dihydrobenzofurans. Synthesis of the Methylated Aglycone
The structures of two novel 2-benzyl-3-O-(methyl-β-D-glucopyranos-2-yl)-trans-2,3-dihydrobenzofurans are elucidated using high resolution 1H n.m.r., 13C n.m.r., and field-desorption mass spectrometry, and also by synthesis of a derivative of the aglycone moiety common to both compounds.
Breytenbach, Jaco C.,Rall, Gerhardus J.H.,Roux, David G.,Hull, William E.
p. 1157 - 1162
(2007/10/02)
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