On the mechanism of formation of pyridines from α,β-unsaturated nitriles and active cyano compounds
The mechanism of formation of pyridines from α,β-unsaturated nitriles and active cyano compounds has been investigated. These processes proceed through a Michael adduct which undergoes a regioselective cyclization to the corresponding heterocyclic compound. The regioselectivity of the heterocyclization processes is justified.
Lorente, Antonio,Alvarez-Barbas, Jose L.,Soto, Jose L.,Gomez-Sal, Pilar,Manzanero, Antonio
p. 33 - 48
(2007/10/02)
Synthese d'heterocycles. XX (1). Reaction du malononitrile avec quelques cinnamonitriles
Reaction of cinnamonitriles with malononitrile, in methanol-methoxide, yield dihydropyridines, which by aromatisation give pyridines.Pyridine is directly obtained when p-nitrocinnamonitrile is used.