Chloride transport across lipid bilayers and transmembrane potential induction by an oligophenoxyacetamide
This contribution describes the discovery and properties of a synthetic, low-molecular weight compound that transports Cl- across bilayer membranes. Such compounds have potential as therapeutics for cystic fibrosis and cancer. The H+/Cl-/
Sidorov, Vladimir,Kotch, Frank W.,Kuebler, Jennifer L.,Lam, Yiu-Fai,Davis, Jeffery T.
Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same
A compound containing at least two aromatic rings covalently bonded together, with each aromatic ring containing at least one oxyacetamide-based side chain, the compound being capable of forming a chloride ion channel across a lipid bilayer, and transporting chloride ion across the lipid bilayer.
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(2008/06/13)
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