- Synthesis and Antifungal Activity of Coumarinimides
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Condensation of 2-hydroxyphenylethylidenebenzylamines (I) with cyanoacetic acid, cyanoacetamide, malononitrile and ethyl cyanoacetate gives coumarinimides, viz. 4-methyl-4-(N-benzylamino)-3,4-dihydrocoumarinimide-3-carboxylic acids (IV), 4-methyl-4-(N-benzylamino)-3,4-dihydrocoumarinimide-3-carboxamides (V), 4-methyl-3-cyanocoumarinimides (VIII) and 4-methylcoumarinimide-3-carboxylic acid ethyl esters (IX), respectively as a result of cyclization due to interaction between 2-hydroxy and nitrile groups of the adducts (II, III) or of addition-elimination products (VI, VII).All the above coumarinimides except VIII show promising antifungal activity in vitro.
- Manrao, M. R.,Kohli, Sunita,Kalsi, P. S.,Sharma, R. C.,Jhooty, J. S.
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p. 1130 - 1132
(2007/10/02)
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