Iridium/monodentate phosphoramidite catalyzed asymmetric hydrogenation of N-aryl imines
(Chemical Equation Presented) Asymmetric hydrogenation of N-aryl acetophenone imines using iridium/PipPhos leads to very high enantioselectivities up to >99percent depending on the presence of electron-donating substituents in the 2-, 3-, and 5-position of the aryl ring. If the substituent is 2-methoxy, the resultant secondary amines are easily oxidatively deprotected using trichloroisocyanuric acid to give the primary amines ingood yield with full retention of enantioselectivity.
Mrsic, Natasa,Minnaard, Adriaan J.,Feringa, Ben L.,Vries, Johannes G. de
supporting information; experimental part
p. 8358 - 8359
(2009/10/23)
Resolution of alpha-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines
The present invention provides a methods and compounds for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.
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Page/Page column 10
(2008/06/13)
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