- Cu(OAc)2-porphyrins as an efficient catalytic system for base-free, nature mimicking Chan–Lam coupling in water
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The use of porphyrins as ligands in organic synthesis reveals the natural process, because these are the constituent motifs of catalysts in many bio-organic reactions. This article presents the synthesis of two N-pincer tetradentate porphyrins; tetrasodium meso-tetra(p-sulfonatophenyl)phorphyrin (H2TSTpSPP) and meso-tetra(m-carboxyphenyl)porphyrin (H2TmCPP), and study on their aptness for Cu-catalyzed C–N coupling reactions of arylboronic acids and amines (Chan–Lam coupling reaction) in water under external base free conditions. The porphyrins and Chan–Lam coupling products were well characterized by their spectral analysis. The high product yields, application of nature-inspired conditions, large extent of substrates, ease of making and handling the ligands, avoidance of base, and use of water as reaction media are the attractive attributes of this finding.
- Venkateswarlu, Katta,Rao, Kanusu Umamaheswara
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- Deciphering the robustness of pyrazolo-pyridine carboxylate core structure-based compounds for inhibiting α-synuclein in transgenic C. elegans model of Synucleinopathy
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Parkinson's disease (PD), a calamitous neurodegenerative disorder with no cure till date, is closely allied with the misfolding and aggregation of α-Synuclein (α -Syn). Inhibition of α-Syn aggregation is one of the optimistic approaches for the treatment for PD. Here, we carried out hypothesis-driven studies towards synthesising a series of pyrazolo-pyridine carboxylate containing compounds (7a–7m) targeted at reducing deleterious α-Syn aggregation. The target compounds were synthesized through multi-step organic synthesis reactions. From docking studies, compounds 7b, 7g and 7i displayed better interaction with the key residues of α-Syn with values: ?6.8, ?8.9 and ?7.2 Kcal/mol, respectively. In vivo transgenic C. elegans model of Synucleinopathy was used to evaluate the ability of the designed and synthesized compounds to inhibit α-Syn aggregation. These lead compounds 7b, 7g and 7i displayed 1.7, 2.4 and 1.5-fold inhibition of α-Syn with respect to the control. Further, the strategy of employing pyrazolo-pyridine-based compounds worked with success and these scaffolds could be further modified and validated for betterment of endpoints associated with PD.
- Hoda, Nasimul,Maqbool, Mudasir,Rajvansh, Roshani,Srividya, Kottapalli
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- COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
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This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.
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Page/Page column 100; 101
(2020/01/31)
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- COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
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This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.
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Page/Page column 174-175
(2020/07/31)
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- Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt
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A synthesis of fluorinated pyrimidines under mild conditions from amidine hydrochlorides and the recently described potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
- Dietz, Jule-Philipp,Lucas, Tobias,Opatz, Till
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p. 445 - 450
(2020/03/27)
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- Synthesis of new conjugates 1H-Pyrazolo[3,4-b]pyridine-phosphoramidate and evaluation against leishmania amazonensis
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In this research three series of substituted 1H-pyrazolo[3,4-b]pyridine phosphoramidates were synthesized and characterized by infrared,1H,13C, and31P nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry. The products were obtained in good yields (67-83percent) under mild conditions by nucleophilic aromatic substitution reaction of aminoalkylphosphoramidates over 4-chloro-1H-pyrazolo[3,4-b]pyridines. These compounds were evaluated as antileishmanials against Leishmania amazonensis promastigotes in vitro. Among all, compounds of a series showed expressive antileishmanial activity. Two of them emerged as the most active, with IC50 values of 6.44 ± 1.49 and 12.25 ± 0.68 μM. The cytotoxicity of this series was assessed on murine cells and presented values similar to the reference drug pentamidine.
- Medeiros, Antonia C. R. F.,Borges, Julio C.,Becker, Klaus M.,Rodrigues, Raquel F.,Leon, Leonor L.,Canto-Cavalheiro, Marilene,Bernardino, Alice M. R.,De Souza, Marcos C.,Pedrosa, Leandro F.
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p. 159 - 167
(2017/12/08)
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- Thermal Ring-Opening of Pyrazolo[3,4-d][1,2,3]triazin-4-ones: An Experimental and Theoretical Study
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Several 3-pyrazolylcarbonyl-pyrazolo[3,4-d][1,2,3]triazin-4-ones have been prepared from 5-amino-1H-pyrazole-4-carbonitriles through a simple sequence. In the first step, diazotization of the corresponding aminopyrazoles afforded pyrazolo[3,4-d][1,2,3]triazin-4-ones. Next, thermal rearrangement of these compounds through nitrogen elimination gave the final products. The proposed mechanism for the ring-opening of the pyrazolotriazinones to give the pyrazolylcarbonyl-pyrazolotriazinones involves the generation of an iminoketene intermediate, which reacts with a second molecule of pyrazolotriazinone. The complete mechanism of product formation involving the iminoketene intermediate, and all other reasonable pathways, have been explored in detail through DFT calculations. Furthermore, additional experiments to corroborate the presence of the iminoketene intermediate were carried out.
- Colomer, Juan P.,Sciú, María L.,Ramirez, Cristina L.,Soria-Castro, Silvia M.,Vera, D. Mariano A.,Moyano, Elizabeth L.
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p. 1514 - 1524
(2018/03/30)
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- Harnessing Cascade Suzuki-Cyclization Reactions of Pyrazolo[3,4-b]pyridine for the Synthesis of Tetracyclic Fused Heteroaromatics
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Numerous procedures have been described for the functionalization of pyrazolo[3,4-b]pyridine, mainly involving nucleophilic substitutions at the C-4 position or esterifications/amidations at the C-5 position. In this paper, we describe a robust, easy to implement protocol for the Suzuki cross-coupling reaction of chloroarene 2, followed by in-situ lactonization to provide chromenopyrazolopyridines. The extension of the scope of the reaction to fused naphthyridinones is also reported. This strategy gave access to 10 original pyrazolopyridine-containing tetracyclic compounds.
- Lavrard, Hubert,Popowycz, Florence
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p. 600 - 608
(2017/02/05)
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- Design, synthesis and anti-P. falciparum activity of pyrazolopyridine–sulfonamide derivatives
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Ten 1-phenyl-1H-pyrazolo[3,4-b]pyridine derivatives connected by a linker group to benzenesulfonamide moieties with different substituents in the 4-position were synthesized and assayed against Plasmodium falciparum. These ten compounds exhibited activity in vitro against the chloroquine-resistant clone W2 with IC50values ranging from 3.46 to 9.30 μM. The most active derivatives with substituent R2= Cl or CH3at the benzenesulfonamide moiety exhibited the lowest IC50. Compounds with an R1= CO2Et substituent at the 5-position of the 1H-pyrazolo[3,4-b]pyridine ring presented lower activity than those with a CN substituent. The 1H-pyrazolo[3,4-b]pyridine system appears to be promising for further studies as an antimalarial for overcoming the burden of resistance in P. falciparum.
- Silva, Thais B.,Bernardino, Alice M.R.,Ferreira, Maria de Lourdes G.,Rogerio, Kamilla R.,Carvalho, Leonardo J.M.,Boechat, Nubia,Pinheiro, Luiz C.S.
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p. 4492 - 4498
(2016/08/23)
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- Copper(I)/Copper(II)-Assisted Tandem Catalysis: The Case Study of Ullmann/Chan-Evans-Lam N1,N3-Diarylation of 3-Aminopyrazole
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Unprecedented CuI/CuII-assisted tandem catalysis allowing an Ullmann/Chan-Evans-Lam sequence was achieved. This three-component, one-pot reaction triggered by a change in the oxidation state of the metal leads to the selective N1,N3-diarylation of 3-aminopyrazole. This new method should be a valuable tool for small-molecule drug discovery that requires suitable regio- and/or chemoselective strategies for the N-arylation of nitrogen-containing heterocycles. Tandem power: The first assisted tandem copper-catalyzed process, triggered by a change in the oxidation state of the metal, is developed to allow a one-pot Ullman/Chan-Evans-Lam sequence leading to the selective N1,N3-diarylation of 3-aminopyrazole.
- Beyer, Astrid,Castanheiro, Thomas,Busca, Patricia,Prestat, Guillaume
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p. 2433 - 2436
(2015/08/24)
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- Regiocontrolled synthesis of 3- and 5-aminopyrazoles, pyrazolo[3,4-d] pyrimidines, pyrazolo[3,4-b]pyridines and pyrazolo[3,4-b]quinolinones as MAPK inhibitors
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Microwave irradiation of a hydrazine and 3-methoxyacrylonitrile, ethoxymethylenemalononitrile or ethyl acetoacetate provides rapid access to 3- or 5-substituted pyrazoles in excellent yield and with total regiocontrol in a process that can be switched from one regioisomer to the other by choice of conditions. Subsequent reaction, either by microwave-assisted hydrolysis and cyclocondensation with formamide, Hantzsch-type three-component reaction with an aldehyde and ketone, or by cyclocondensation with 2-nitrobenzaldehyde, provides the pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-b]pyridine or pyrazolo[3,4-b] quinolin-4-one framework, respectively, of inhibitors of mitogen-activated protein kinases.
- Bagley, Mark C.,Baashen, Mohammed,Paddock, Victoria L.,Kipling, David,Davis, Terence
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p. 8429 - 8438
(2013/09/02)
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- TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS
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The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.
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Page/Page column 31
(2011/04/25)
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- SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS
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The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
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Page/Page column 48
(2010/04/06)
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- TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS
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The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.
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Page/Page column 75
(2010/01/07)
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- A tandem decarboxylation/Diels-Alder reaction of 5-amino-1-phenyl-4-pyrazolecarboxylic acid with 1,3,5-triazines
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A tandem decarboxylation/Diels-Alder reaction of 5-amino-1-phenyl-4-pyrazolecarboxylic acid with various 1,3,5-triazines was reported. The dienophile, 5-amino-1-phenylpyrazole, was generated in situ via decarboxylation and immediately trapped by 1,3,5-triazines leading to 4,6-disubstituted 1-phenylpyrazolo[3,4-d]pyrimidines in one step.
- Dang, Qun,Liu, Yan,Sun, Zhili
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p. 8419 - 8422
(2007/10/03)
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- Mono- and di-sulfo group containing compound having a substituted pyrazolyl diazo component radical and their use
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Monoazo compounds of formula STR1 wherein R1 is a coupling component radical, R1 is C1-6 alkyl; C1-6 alkyl substituted by 1 or 2 substituents selected from chloro, cyano, hydroxy, C1-4 alkoxy, phenyl and phenyl substituted by 1 or 2 substituents selected from chloro, C1-4 alkyl, C1-4 alkoxy, carboxy, sulfo, sulfamoyl and acetamido; C5-7 cycloalkyl; C5-7 cycloalkyl substituted by 1 to 3 C1-4 alkyl groups; phenyl; phenyl substituted by 1 to 3 substituents selected from chloro, C1-4 alkyl, C1-4 alkoxy, acetamido (maximum of 1), carboxy (maximum of 1), sulfo (maximum of 1) and --SO2 NR7 R8 (maximum of 1); 1- or 2-naphthyl or 1- or 2-naphthyl substituted by sulfo, wherein each of R7 and R8 is independently hydrogen; C1-4 alkyl; C1-4 alkyl monosubstituted by hydroxy or phenyl; cyclohexyl; phenyl or phenyl monosubstituted by chloro, methyl or methoxy, or --NR7 R8 is a 5- or 6-membered saturated or unsaturated ring containing 1 or 2 hetero atoms, R2 is hydrogen; C1-4 alkyl; C1-4 alkyl monosubstituted by hydroxy, chloro, cyano, C1-4 alkoxy, phenyl or phenyl substituted by 1 or 2 substituents selected from chloro, methyl, methoxy, sulfo and sulfamoyl; C1-4 alkoxy; cyano; phenyl; phenoxy; or phenyl or phenoxy monosubstituted by chloro, methyl, methoxy or sulfo, and R3 is cyano, carbamoyl, --COOR4, sulfo or --CO2 NR5 R6, wherein R4 is hydrogen, C1-4 alkyl, phenyl or phenyl(C1-4 alkyl), and each of R5 and R6 is independently hydrogen; C1-4 alkyl; C1-4 alkyl monosubstituted by hydroxy or phenyl; cyclohexyl; phenyl or phenyl monosubstituted by chloro, methyl or methoxy, or --NR5 R6 is a 5- or 6-membered saturated or unsaturated ring containing 1 or 2 hetero atoms, with the provisos that (i) the total number of sulfo groups is 1 or 2 and (ii) R1, R2 or R3 must contain a sulfo group when K1 is a coupling component radical of the aminobenzene series the amino group of which is substituted by an alkylene radical having a terminal sulfo or sulfato group, by a bridge member-containing alkylene radical having a terminal sulfo or sulfato group or by a phenylalkyl group the phenyl group of which has a sulfo substituent, are useful for dyeing or printing anionically dyeable substrates such as natural or synthetic polyamides, especially nylon carpet.
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- Aminopyrazoles. IV. Pyrazol-3- and 5-amines from 2,3-dihaloalkanenitriles or 3-Chloroacrylonitriles and Hydrazines
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2,3-Dihalopropanenitriles and substituted 3-chloropropenenitriles react with hydrazines in basic solution to form either pyrazol-3-amines 4 or pyrazol-5-amines 5 or a mixture of both isomers.
- Ege, Guenter,Franz, Hermann
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p. 1267 - 1273
(2007/10/02)
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- Aminopyrazoles. III. Novel "One-Flask" Preparation of 1-Phenylpyrazol-3-amine
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2-Chloroacrylonitrile (1a), 2,3-dichloropropanenitrile (1b), 2,3-dibromopropanenitrile (1c) or 3-chloroacrylonitrile (1d) react with phenylhydrazine (2) in the presence of potassium t-butoxide with the formation of 1-phenylpyrazol-3-amine (3) free of the 5-amino isomer.
- Ege, Guenter,Franz, Hermann
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p. 1265 - 1266
(2007/10/02)
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- Studies on the Synthesis of Heterocyclic Compounds. Part VI. The Action of Methyl Salicylate on Some 5-Aminopyrazoles
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Some 1-phenyl-3-R-5-aminopyrazoles reacted with methyl salicylate to give N-(1-phenyl-3-R-pyrazol-5-yl)-2-methoxybenzamides (3a,b,c), 1-phenyl-2-methyl-3-R-salicyloilimino-3-pyrazolines (4a,b,c) together with 1-phenyl-3-R-5-methylamino pyrazoles (5a,b,c).The structures of the new compounds 3 and 4 were determined on the basis of analytical and spectroscopic data as well as on the acid hydrolysis products.
- Daidone, Giuseppe,Plescia, Salvatore
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p. 747 - 750
(2007/10/02)
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