826990-47-0

Basic information

• Product Name: (3-chloro-4-fluorophenoxy)acetyl chloride
• Synonyms: (3-chloro-4-fluorophenoxy)acetyl chloride;acetyl chloride, (3-chloro-4-fluorophenoxy)-;2-(3-chloro-4-fluorophenoxy)acetyl chloride;2-(3-chloro-4-fluoro-phenoxy)acetyl chloride;2-(3-chloro-4-fluoro-phenoxy)ethanoyl chloride
• CAS NO: 826990-47-0
• Molecular Formula: C₈H₅Cl₂FO₂
• Molecular Weight: 223.0285032
• Mol File: 826990-47-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3-chloro-4-fluorophenoxy)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (3-chloro-4-fluorophenoxy)acetyl chloride(826990-47-0)
• EPA Substance Registry System: (3-chloro-4-fluorophenoxy)acetyl chloride(826990-47-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 826990-47-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(3-chloro-4-fluorophenoxy)acetyl chloride is used as a reagent for the introduction of the (3-chloro-4-fluorophenoxy)acetyl group into various organic molecules. This allows for the creation of new compounds with specific properties and functions.
Used in Pharmaceutical Production:
(3-chloro-4-fluorophenoxy)acetyl chloride is used as an intermediate in the synthesis of pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Production:
(3-chloro-4-fluorophenoxy)acetyl chloride is used in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties make it suitable for the development of effective and targeted agricultural products.
Used in Polymer Manufacturing:
(3-chloro-4-fluorophenoxy)acetyl chloride is used in the manufacturing of polymers. Its incorporation into polymer structures can enhance their properties, such as strength, stability, and resistance to environmental factors.
Used in Other Industrial Processes:
(3-chloro-4-fluorophenoxy)acetyl chloride has applications in various industrial processes, where its unique chemical properties can be utilized for specific purposes, such as in the production of specialty chemicals or materials.

Upstream product

• 667437-18-5 ethyl 3-chloro-4-fluoro-phenoxyacetate 
• 331-40-8 2-(3-chloro-4-fluorophenoxy)acetic acid 

Downstream Products

• 866146-06-7 O,O-dimethyl α-(3-chloro-4-fluorophenoxyacetoxy)-3-nitrobenzylphosphonate 
• 866145-57-5 O,O-dimethyl α-(3-chloro-4-fluorophenoxyacetoxy)benzylphosphonate 
• 866145-41-7 O,O-dimethyl α-(3-chloro-4-fluorophenoxyacetoxy)ethylphosphonate 
• 866145-51-9 O,O-dimethyl 1-(3-chloro-4-fluorophenoxyacetoxy)-2,2,2-trichloroethylphosphonate 
• 826990-57-2 [(3-chloro-4-fluorophenoxyacetyl)(ethoxycarbonyl)methylene]triphenylphosphorane 
• 826990-51-6 [(3-chloro-4-fluorophenoxyacetyl)(cyano)methylene]triphenylphosphorane 

Relevant articles and documents

NOVEL PYRIDOPYRIMIDINONE COMPOUNDS FOR MODULATING THE CATALYTIC ACTIVITY OF HISTONE LYSINE DEMETHYLASES (KDMS)

The present invention provides a compound of Formula (I) being capable of modulating the activity of histone lysine demethylase (KDM), pharmaceutical compositions thereof, methods to prepare the said compounds, and the use of such compounds as a medicament. The compound of Formula (I) acts as KDM inhibitor with marked potency, thereby having an outstanding potential for a pharmaceutical intervention of cancer and any other diseases related to KDM dysregulation.

Studies of O,O-Dimethyl α-(2,4-Dichlorophenoxyacetoxy) ethylphosphonate (HW02) as a new herbicide. 1. Synthesis and herbicidal activity of HW02 and analogues as novel inhibitors of pyruvate dehydrogenase complex

On the basis of the previous work for optimization of O,O-diethyl α-(substituted phenoxyacetoxy)alkylphosphonates, further extensive syntheticmodifications were made to the substituents in alkylphosphonate and phenoxymoieties of the title compounds. New O,O-dimethyl α-(substituted phenoxyacetoxy)alkylphosphonates were synthesized as potential inhibitors of pyruvate dehydorogenase complex (PDHc). Their herbicidal activity and efficacy in vitro against PDHc were examined. Some of these compounds exhibited significant herbicidal activity and were demonstrated to be effective inhibitors of PDHc from three different plants. The structure-activity relationships of these compounds including previously reported analogous compoundswere studied by examining their herbicidal activities. Both inhibitory potency against PDHc and herbicidal activity of title compounds could be increased greatly by optimizing substituent groups of the title compounds. O,O-Dimethyl α-(2,4- dichlorophenoxyacetoxy)ethylphosphonate (I-5), which acted as a competitive inhibitor of PDHc with much higher inhibitory potency against PDHc from Pisum sativum and Phaseolus radiatus than from Oryza sativa, was found to be themost effective compound against broadleaf weeds and showed potential utility as herbicide.

One-pot synthesis of fluorine containing 3-cyano/ethoxycarbonyl-2-methyl- benzo[b]furans

Fluoro-substituted 3-cyano-2-methyl-benzo[b]furans and ethyl 2-methyl-benzo[b]furan-3-carboxylates are conveniently prepared in a single step in good yield by the microwave induced tandem intramolecular Wittig and Claisen rearrangement reactions of the corresponding [(aryloxyacetyl) (cyano) methylene] triphenylphosphorane and [(aryloxyacetyl) (ethoxycarbonyl) methylene] triphenylphosphoranes, respectively. Graphical Abstract