(S)-o-N-(N-Benzylprolyl)aminobenzaldehyde and (S)-o-N-(N-Benzylprolyl)aminoacetophenone as Reagents for Asymmetric Synthesis of Threonine
Chiral aldehydes and ketones, derivatives of proline and piperidine-2-carboxylic acid have been synthesized and their Schiff bases with glycine form copper complexes which were hydroxyethylated with acetaldehyde; decomposition of the complexes obtained gave threonine with an optical purity of up to 97-100percent and with threo/allo ratios of up to 19 : 1, and the chiral reagents can be recovered and reused with no loss of optical purity of the threonine.
Belokon, Yuuri N.,Zeltzer, Irina E.,Ryzhov, Michail G.,Saporovskaya, Marina B.,Bakhmutov, Vladimir I.,Belikov, Vasili M.
p. 180 - 181
(2007/10/02)
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