827605-45-8

Basic information

• Product Name: 4(3H)-Quinazolinone, 2-chloro-6,7-dimethoxy-5-methyl-
• Synonyms: 4(3H)-Quinazolinone, 2-chloro-6,7-dimethoxy-5-methyl-
• CAS NO: 827605-45-8
• Molecular Formula: C₁₁H₁₁ClN₂O₃
• Molecular Weight: 254.66964
• Mol File: 827605-45-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4(3H)-Quinazolinone, 2-chloro-6,7-dimethoxy-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 2-chloro-6,7-dimethoxy-5-methyl-(827605-45-8)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 2-chloro-6,7-dimethoxy-5-methyl-(827605-45-8)

Safety Data

• Hazardous Substances Data: 827605-45-8(Hazardous Substances Data)

Upstream product

• 827605-44-7 2,4-dichloro-6,7-dimethoxy-5-methylquinazoline 

Downstream Products

• 828242-87-1 2-[(3-methanesulfinylmethoxy-benzyl)-methyl-amino]-6,7-dimethoxy-5-methyl-1H-quinazolin-4-one 
• 828244-22-0 6,7-dimethoxy-5-methyl-2-{methyl-[3-(pyrimidin-2-yloxy)-benzyl]-amino}-1H-quinazolin-4-one 
• 828243-28-3 6,7-dimethoxy-5-methyl-2-{methyl-[3-(1-methyl-piperidin-4-yl)benzyl]-amino}-1H-quinazolin-4-one 
• 828242-26-8 3-{[(6,7-dimethoxy-5-methyl-4-oxo-1,4-dihydro-quinazolin-2-yl)-methyl-amino]-methyl}-benzonitrile 
• 828242-35-9 6,7-dimethoxy-5-methyl-2-[methyl-(3-methylaminomethyl-benzyl)-amino]-1H-quinazolin-4-one 
• 828242-25-7 2-[(3-aminobenzyl)(methyl)amino]-6,7-dimethoxy-5-methyl-1H-quinazolin-4-one 
• 828244-42-4 N'-(3-{[(6,7-dimethoxy-5-methyl-4-oxo-1,4-dihydroquinazolin-2-yl)methylamino]methyl}phenyl)-N,N-dimethylacetamidine 

Relevant articles and documents

Concise synthesis of a selective α1-adrenoceptor antagonist

An efficient synthesis of an adrenoceptor antagonist has been developed and demonstrated in a pilot plant. A linear synthesis that relied on a catalytic reduction of a rather insoluble nitroaromatic proved to be a viable route. The active pharmaceutical ingredient (API) that contained an amidine functional group was generated from the amino-containing precursor by activation of dimethylacetamide (DMA) with phosphorus oxychloride (POCl3). The reaction between DMA and POCl3 was studied using ReactIR and was found to be a fast but not instantaneous reaction. The iminium salt generated from DMA and POCl3 had acceptable stability to allow for its use on a pilot-plant scale; however, a trend towards decomposition was revealed on the basis of in situ FTIR data. Formation of the complex was evaluated in a reaction calorimeter (RC-1), and the stability of the complex was probed with an Advanced Reactive System Screening Tool (ARSST).

ARYLAMINE-SUBSTITUTED QUINAZOLINONE COMPOUNDS

Compounds represented by Formula (I) which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of making said compounds, wherein Ar, Z, R, R', R