- PROCESS FOR THE PREPARATION OF FUROPYRROLES
-
The present invention relates to a process for the preparation of furopyrroles of the general formula (I), comprising (a) heating a compound of the formula (II) under microwave irradiation optionally in the presence of an inert solvent, wherein A1
- -
-
Page/Page column 21
(2010/02/10)
-
- Synthetic studies related to diketopyrrolopyrrole (DPP) pigments. Part 2: The use of esters in place of nitriles in standard DPP syntheses: Claisen-type acylations and furopyrrole intermediates
-
Ethyl 2-aryl-4,5-dihydro-5-oxopyrrole-3-carboxylates react with esters or acyl halides in the presence of a strong base to give 4-acyl derivatives, which exist predominantly as either E- or Z-enols. These are cyclised, either in solution at temperatures >200°C or by microwave irradiation, to 3,6-disubstituted 1H-furo[3,4-c]pyrrolediones which, after N-protection, are convertible by reaction with primary amines into novel N,N′-disubstituted DPP derivatives. Graphical Abstract.
- Morton, Colin J.H.,Riggs, Richard L.,Smith, David M.,Westwood, Nicholas J.,Lightfoot, Philip,Slawin, Alexandra M.Z.
-
p. 727 - 738
(2007/10/03)
-