Investigation of the conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II: Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro
2,6-Dichloro-4-hydroxybenzylamine (1) and its N-methyl (2) and N-ethyl (3) derivatives were synthesized and tested for estrogen receptor affinity as well as for estrogenic activity. In contrast to their related highly active 1,2-bis(2,6-dichloro-4-hydroxy
Gust,Schonenberger
p. 763 - 769
(2007/10/02)
Effect of N,N'-Diethyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines on the 7,12-Dimethylbenzanthracene-Induced Mammary Carcinoma of the Rat
The syntheses and estrogen receptor affinities of meso- and (+/-)-N,N'-dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines (2) are described.They show high binding affinities in both diastereomeric forms but with a preference for the meso isomer
Angerer, Erwin von
p. 1374 - 1377
(2007/10/02)
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