An Excursion into the Synthesis of Potential Angiotensin Converting Enzyme Inhibitors
An attempt to prepare dehydro analogues of 1 gave the expected tripeptide 2a, but rearrangement of a thiazolone derivative of ΔZ-Phe made only a thiazolinecarboxylic acid (8) available.The latter was also converted into a tripeptide (11) and both compounds, 2a and 11, showed moderate angiotensin converting enzyme inhibition.
Nitz, Theodore J.,Lindsey, John,Stammer, Charles H.
p. 4029 - 4032
(2007/10/02)
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