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831217-43-7

1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]is a complex organic compound with a unique chemical structure. It is characterized by a pyrimidinehexanoic acid core, a biphenyl group, a methyl group, and a phenylmethoxycarbonyl moiety. 1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]has potential applications in various fields due to its specific chemical properties and interactions.

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  • 1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]-

    Cas No: 831217-43-7

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  • 831217-43-7 Structure

  • Basic information

    1. Product Name: 1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]-
    2. Synonyms: 4-[1,1′-Biphenyl]-4-yl-3,4-dihydro-6-methyl-2-oxo-5-[(phenylmethoxy)carbonyl]-1(2H)-pyrimidinehexanoic acid;1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]-;116-9e;6-(4-([1,1'-biphenyl]-4-yl)-5-((benzyloxy)carbonyl) -6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)hexanoic acid
    3. CAS NO:831217-43-7
    4. Molecular Formula: C31H32N2O5
    5. Molecular Weight: 512.59618
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 831217-43-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: white to off-white/
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: DMSO: >20mg/mL
    9. CAS DataBase Reference: 1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]-(831217-43-7)
    11. EPA Substance Registry System: 1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]-(831217-43-7)

  • Safety Data

    1. Hazard Codes: T,N
    2. Statements: 25-50/53
    3. Safety Statements: 45-60-61
    4. RIDADR: UN 2811 6.1 / PGIII
    5. WGK Germany: 3
    6. RTECS:
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 831217-43-7(Hazardous Substances Data)

831217-43-7 Usage

Uses

Used in Pharmaceutical Research:
1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]is used as an inhibitor of heat shock protein 70 (Hsp70) co-chaperone HDJ2 (human Ydj1/DNAJA1) for studying the influence of HDJ2 on the regulation of ribonucleotide reductase (RNR) activity in HEK293 cells. This application helps researchers understand the role of HDJ2 in cellular processes and its potential as a therapeutic target.
Used in Cellular Biology Studies:
1(2H)-PyriMidinehexanoic acid, 4-[1,1'-biphenyl]-4-yl-3,4-dihydro-6-Methyl-2-oxo-5-[(phenylMethoxy)carbonyl]is also used as an Hsp70 inhibitor to study the effect of Hsp70 chaperone on b5‐ops glycosylation in the side populations (SP) HeLa cells. By inhibiting Hsp70, researchers can investigate the role of this chaperone protein in cellular processes and its potential involvement in various diseases.

Biochem/physiol Actions

116-9e is a dihhydropyrimidine compound.

Check Digit Verification of cas no

The CAS Registry Mumber 831217-43-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,3,1,2,1 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 831217-43:
(8*8)+(7*3)+(6*1)+(5*2)+(4*1)+(3*7)+(2*4)+(1*3)=137
137 % 10 = 7
So 831217-43-7 is a valid CAS Registry Number.

831217-43-7 Well-known Company Product Price

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  • Sigma

  • (E1036)  116-9e  ≥98% (HPLC), powder

  • 831217-43-7

  • E1036-5MG

  • 1,306.89CNY

  • Detail

  • Sigma

  • (E1036)  116-9e  ≥98% (HPLC), powder

  • 831217-43-7

  • E1036-25MG

  • 5,266.17CNY

  • Detail

831217-43-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-[4-methyl-2-oxo-5-phenylmethoxycarbonyl-6-(4-phenylphenyl)-1,6-dihydropyrimidin-3-yl]hexanoic acid

1.2 Other means of identification

Product number -
Other names UPCMLD00WMAL2-11B

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:831217-43-7 SDS

831217-43-7Relevant articles and documents

Synthesis and structure-activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target

Ireland, Alex W.,Gobillot, Theodore A.,Gupta, Tushar,Seguin, Sandlin P.,Liang, Mary,Resnick, Lynn,Goldberg, Margot T.,Manos-Turvey, Alexandra,Pipas, James M.,Wipf, Peter,Brodsky, Jeffrey L.

, p. 6490 - 6502 (2014)

Polyomavirus infections are common and relatively benign in the general human population but can become pathogenic in immunosuppressed patients. Because most treatments for polyomavirus-associated diseases nonspecifically target DNA replication, existing

A focused library of tetrahydropyrimidinone amides via a tandem Biginelli-Ugi multi-component process

Werner, Stefan,Turner, David M.,Lyon, Michael A.,Huryn, Donna M.,Wipf, Peter

, p. 2334 - 2338 (2006)

A second generation focused library of 30 tetrahydropyrimidinone amides was prepared. The design was based on the structure of an Hsp70 modulator. This small library demonstrates the utility of tandem multi-component reactions in structure-activity relati

Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation

Wright, Christine M.,Chovatiya, Raj J.,Jameson, Nora E.,Turner, David M.,Zhu, Guangyu,Werner, Stefan,Huryn, Donna M.,Pipas, James M.,Day, Billy W.,Wipf, Peter,Brodsky, Jeffrey L.

, p. 3291 - 3301 (2008/09/19)

The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-

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