83140-94-7

Basic information

• Product Name: [3-(1H-PYRROL-1-YL)PHENYL]METHANOL
• Synonyms: RARECHEM AL BD 1294;BUTTPARK 96\50-03;[3-(1H-PYRROL-1-YL)PHENYL]METHANOL
• CAS NO: 83140-94-7
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.21
• Mol File: 83140-94-7.mol

Chemical Properties

• Melting Point: 70 °C
• Boiling Point: 334.7°C at 760 mmHg
• Flash Point: 156.2°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 4.97E-05mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: [3-(1H-PYRROL-1-YL)PHENYL]METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(1H-PYRROL-1-YL)PHENYL]METHANOL(83140-94-7)
• EPA Substance Registry System: [3-(1H-PYRROL-1-YL)PHENYL]METHANOL(83140-94-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 83140-94-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
[3-(1H-PYRROL-1-YL)PHENYL]METHANOL is used as a building block for the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure allows for the creation of diverse molecules with potential applications in medicine and other fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, [3-(1H-PYRROL-1-YL)PHENYL]METHANOL is used as a precursor for the development of new drugs. Its structural resemblance to other bioactive molecules makes it a promising candidate for therapeutic applications.
Used as a Reagent in Chemical Reactions:
[3-(1H-PYRROL-1-YL)PHENYL]METHANOL is also used as a reagent in chemical reactions to introduce the pyrrole and phenyl rings into other molecules. This capability enhances the functionalization of various organic compounds, broadening the scope of chemical synthesis.
Used in Pharmaceutical Industry:
[3-(1H-PYRROL-1-YL)PHENYL]METHANOL is used as a key intermediate in the synthesis of pharmaceuticals. Its presence in the molecular structure of certain drugs contributes to their therapeutic effects, making it an essential component in the development of new medications.
Used in Research and Development:
In research and development, [3-(1H-PYRROL-1-YL)PHENYL]METHANOL is utilized for studying the properties and potential applications of pyrrole and phenyl-containing compounds. Its unique structure provides insights into the design and synthesis of novel molecules with specific biological activities.

InChI:InChI=1/C11H11NO/c13-9-10-4-3-5-11(8-10)12-6-1-2-7-12/h1-8,13H,9H2

Upstream product

• 83140-93-6 methyl 3-(1H-pyrrol-1-yl)benzoate 
• 83140-93-6 ethyl 3-(pyrrol-1-yl)benzoate 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 1877-77-6 3-aminobenzenemethanol 
• 4518-10-9 Methyl 3-aminobenzoate 

Downstream Products

• 112575-86-7 3-pyrrol-1-ylbenzeneethanenitrile 
• 112575-87-8 3-pyrrol-1-ylphenylacetic acid 
• 112575-85-6 methyl 3-pyrrol-1-ylphenylacetate 
• 112596-35-7 (3-Pyrrol-1-yl-phenyl)-acetic acid hydrazide 
• 1202576-73-5 (6A) Ethyl 3-ethoxy-3-(4-{[3-(1H-pyrrol-1-yl)benzyl]oxy}phenyl)propionate 
• 112596-36-8 1-[3-(bromomethyl)phenyl]-1H-pyrrole 

Relevant articles and documents

Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

The free fatty acid receptor 1 (FFA1) has gained significant interest as a novel antidiabetic target. Most of FFA1 agonists reported in the literature bearing a common biphenyl scaffold, which was crucial for toxicity verified by the researchers of Daiichi Sankyo. Herein, we describe the systematic exploration of non-biphenyl scaffold and further chemical modification of the optimal pyrrole scaffold. All of these efforts led to the identification of compound 11 as a potent and orally bioavailable FFA1 agonist without the risk of hypoglycemia. Further molecular modeling studies promoted the understanding of ligand-binding pocket and might help to design more promising FFA1 agonists.

Novel nitrogen-containing heterocyclic derivative and preparation method thereof and application of derivative by serving as drug

The invention relates to a novel nitrogen-containing heterocyclic derivative shown as a general formula (I) (please see the formula in the description) and a preparation method thereof and application of a pharmaceutical composition containing the derivative in preparation of a drug for treating diabetes and a metabolic syndrome. The nitrogen-containing heterocyclic derivative has the excellent in-vivo hypoglycemic activity and can be used for preventing or treating the diabetes.

Substituted alkylamine derivatives

The substituted alkylamine derivatives represented by formula (I) STR1 wherein R1 represents (a) substituted or unsubstituted C2-6 alkenyl group, (b) substituted or unsubstituted C3-6 cycloalkenyl group, (c) substituted or unsubstituted C2-6 alkynyl group, (d) substituted or unsubstituted aryl group, (e) substituted or unsubstituted heterocyclic group, (f) fused heterocyclic group which may be substituted, or (g) group represented by the formula Ru11 -Ar wherein R11 is a heterocyclic group and Ar is a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and which may be substituted; STR2 represents a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and may be substituted by R7, X and Y are linking groups, R2 is H or lower alkyl, R3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl or lower cycloalkyl, R4 and R5 are independently hydrogen or halogen atoms, R6 represents (a) substituted or unsubstituted acyclic hydrocarbon group which may be unsaturated, (b) substituted or unsubstituted cycloalkyl group, or (c) substituted or unsubstituted phenyl group, or non-toxic salts thereof. (E)-N-(6-6-dimethyl-2-hepten-4-ynyl)-N-ethyl-3-[4-(3-thienyl)-2-thienyl-methyloxy]benzylamine hydrochloride is a representative example. The substituted alkylamine derivatives are useful as pharmaceuticals, particularly for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.

Inhibition of Copper-Dependent Amine Oxidases by Some Hydrazides of Pyrrol-1-ylbenzoic and Pyrrol-1-ylphenylacetic Acids

Some hydrazides of pyrrol-1-ylbenzoic and pyrrol-1-ylphenylacetic acids were prepared, and their effect on copper-dependent amine oxidases (Cu-AOs) and FAD monoamine oxidases (MAOs) activities was tested.The compounds were not substrates for Cu-AO enzymes

3-(Pyrrol-1-yl)phenylmethyl esters and intermediates

3-(Pyrrol-1-yl)phenylmethyl esters and intermediates having the general formula STR1 the use of the esters as pesticides, compositions thereof and a process for preparation are disclosed and exemplified.