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(4-METHYL-PIPERAZINE-1-YL)-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PHENYL]-METHANONE is a complex organic molecule characterized by the presence of a piperazine group and a boron-containing phenyl ring. With a molecular formula of C21H30BNO2N2 and a molecular weight of 357.29 g/mol, this compound holds promise in pharmaceutical research and drug development due to its potential therapeutic properties.

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  • (4-Methylpiperazin-1-yl)(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone

    Cas No: 832114-06-4

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  • (4-METHYL-PIPERAZINE-1-YL)-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PHENYL]-METHANONE

    Cas No: 832114-06-4

  • USD $ 10.0-10.0 / Milligram

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  • 832114-06-4 Structure
  • Basic information

    1. Product Name: (4-METHYL-PIPERAZINE-1-YL)-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PHENYL]-METHANONE
    2. Synonyms: (4-METHYL-PIPERAZINE-1-YL)-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PHENYL]-METHANONE;4-(4-METHYLPIPERAZINE-1-CARBONYL)PHENYLBORONIC ACID, PINACOL ESTER;4-(4-Methyl-1-piperazinylcarbonyl)benzeneboronic acid pinacol ester, 97%;(4-Methyl-piperazine-1-yl)-[4-(4;2-dioxaborolan-2-yl)-phenyl]-Methanone;5-tetraMethyl-1;1-Methyl-4-{[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbonyl}piperazine;(4-Methylpiperazin-1-yl)(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanone
    3. CAS NO:832114-06-4
    4. Molecular Formula: C18H27BN2O3
    5. Molecular Weight: 330.23
    6. EINECS: 200-528-9
    7. Product Categories: Aryl Boronate Esters;Boronate Esters;Boronic Acids and Derivatives;Chemical Synthesis;Organometallic Reagents
    8. Mol File: 832114-06-4.mol
  • Chemical Properties

    1. Melting Point: 110-113°C
    2. Boiling Point: 463.3°C at 760 mmHg
    3. Flash Point: 234°C
    4. Appearance: /
    5. Density: 1.12g/cm3
    6. Vapor Pressure: 9.21E-09mmHg at 25°C
    7. Refractive Index: 1.547
    8. Storage Temp.: Inert atmosphere,Room Temperature
    9. Solubility: N/A
    10. PKA: 6.71±0.10(Predicted)
    11. CAS DataBase Reference: (4-METHYL-PIPERAZINE-1-YL)-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PHENYL]-METHANONE(CAS DataBase Reference)
    12. NIST Chemistry Reference: (4-METHYL-PIPERAZINE-1-YL)-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PHENYL]-METHANONE(832114-06-4)
    13. EPA Substance Registry System: (4-METHYL-PIPERAZINE-1-YL)-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PHENYL]-METHANONE(832114-06-4)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 832114-06-4(Hazardous Substances Data)

832114-06-4 Usage

Uses

Used in Pharmaceutical Research and Drug Development:
(4-METHYL-PIPERAZINE-1-YL)-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PHENYL]-METHANONE is utilized as a compound of interest in pharmaceutical research and drug development for its potential therapeutic properties. It may contribute to the treatment of various diseases and disorders, although further research is necessary to fully understand its potential uses and effects.
Used in the Treatment of Various Diseases and Disorders:
In the medical field, (4-METHYL-PIPERAZINE-1-YL)-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PHENYL]-METHANONE is considered for its potential application in the treatment of a range of diseases and disorders. Its specific applications are yet to be determined through ongoing research, but its unique molecular structure suggests it may have a role in addressing unmet medical needs.

Check Digit Verification of cas no

The CAS Registry Mumber 832114-06-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,3,2,1,1 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 832114-06:
(8*8)+(7*3)+(6*2)+(5*1)+(4*1)+(3*4)+(2*0)+(1*6)=124
124 % 10 = 4
So 832114-06-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H27BN2O3/c1-17(2)18(3,4)24-19(23-17)15-8-6-14(7-9-15)16(22)21-12-10-20(5)11-13-21/h6-9H,10-13H2,1-5H3

832114-06-4 Well-known Company Product Price

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  • Alfa Aesar

  • (H28216)  4-(4-Methyl-1-piperazinylcarbonyl)benzeneboronic acid pinacol ester, 97%   

  • 832114-06-4

  • 1g

  • 695.0CNY

  • Detail
  • Alfa Aesar

  • (H28216)  4-(4-Methyl-1-piperazinylcarbonyl)benzeneboronic acid pinacol ester, 97%   

  • 832114-06-4

  • 5g

  • 1930.0CNY

  • Detail
  • Aldrich

  • (706175)  4-(4-Methylpiperazine-1-carbonyl)phenylboronicacidpinacolester  97%

  • 832114-06-4

  • 706175-1G

  • 1,105.65CNY

  • Detail
  • Aldrich

  • (706175)  4-(4-Methylpiperazine-1-carbonyl)phenylboronicacidpinacolester  97%

  • 832114-06-4

  • 706175-5G

  • 3,247.92CNY

  • Detail

832114-06-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-METHYL-PIPERAZINE-1-YL)-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PHENYL]-METHANONE

1.2 Other means of identification

Product number -
Other names (4-methylpiperazin-1-yl)-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:832114-06-4 SDS

832114-06-4Relevant articles and documents

Derivatives with uracil-benzothiazole structure, preparation method of derivatives, and application of anti-HCV drugs

-

, (2019/12/02)

According to the invention, a new series of uracil-benzothiazole NS5B RdRp inhibitors are designed and synthesized; the compounds have the structure shown in a general formula (1), wherein the uracil-benzothiazole NS5B RdRp inhibitor provided by the inven

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Taylor, Nicholas J.,Emer, Enrico,Preshlock, Sean,Schedler, Michael,Tredwell, Matthew,Verhoog, Stefan,Mercier, Joel,Genicot, Christophe,Gouverneur, Véronique

, p. 8267 - 8276 (2017/06/27)

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

PYRROLO[3,2-C]PYRIDINE DERIVATIVES AS TLR INHIBITORS

-

Paragraph 0661; 0662, (2017/01/31)

The present invention provides a heterocyclic compound having a TLR7, TLR9, TLR7/8, TLR7/9 or TLR7/8/9 inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases, inflammatory diseases and the like, in particular, systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, psoriasis, inflammatory bowel disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

Thienopyrimidine and furan and pyrimidine derivatives, its preparation process and its use in medicine

-

Paragraph 0071-0073, (2016/10/09)

Disclosed are thienopyrimidine and furopyrimidine derivatives, the preparation method thereof and the medical use thereof. The derivatives have a structure as shown in formula V. The thienopyrimidine and furopyrimidine derivatives provided in the present invention have dominant EGFR inhibiting activity, and some of these compounds also have dominant inhibiting activity against VEGFR; therefore, same can expect to be developed as tyrosine kinase EGFR and/or VEGFR inhibitors, and to be used for preparing the drugs for preventing or treating the diseases related to epidermal growth factor receptor EGFR and/or vascular endothelial growth factor receptor VEGFR. Provided is a new development direction and approach for developing novel tyrosine kinase inhibitor drugs having low drug resistance or able to relieve drug resistance to the inhibitor in the early stages, thereby having extensive application prospects and medical value.

3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE

-

Page/Page column 196; 197, (2015/03/28)

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3-aryl-5-substituted- 2/-/-isoquinolin-1-one compounds that, inter alia, inhibit PARP (e.g., PARP1, TNKS1, TNKS2, e

PYRROLO[3,2-C]PYRIDINE DERIVATIVES AS TLR INHIBITORS

-

Paragraph 0243-0245, (2016/12/16)

The present invention provides a heterocyclic compound having a TLR7, TLR9, TLR7/8, TLR7/9 or TLR7/8/9 inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases, inflammatory diseases and the like, in particular, systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, psoriasis, inflammatory bowel disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE

-

Page/Page column 116, (2011/12/14)

Provided are compounds having an inhibitory effect on kinases including Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders that comprise the inhibition of Mixed Lineage Kinases.

MLK INHIBITORS AND METHODS OF USE

-

Page/Page column 118, (2010/07/02)

Provided are compounds having an inhibitory effect on Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders which comprise the inhibition of Mixed Lineage Kinases.

AROMATIC COMPOUND

-

Page/Page column 77, (2008/12/07)

An aromatic compound represented by the following formula or a pharmaceutically acceptable salt thereof: , wherein ring A is a heterocyclic ring, ring B is a carbocyclic ring, a heterocyclic ring etc., G1, G2, G3, G4 and G5 are CH or N, X is -NH-, -O-, -CH2-, etc., Y is - CH2-,-CO-,-SO2- etc., Z is a single bond, -CO-, -SO2-, -NH-, -O-, -S-, -CONH-,-SO2NH-, etc., R2 is hydrogen, alkyl, alkoxy, halogen, etc., and R3 is carbocyclic group, heterocyclic group, alkyl, etc., is useful as a controlling agent of the function of CCR4 useful for the treatment or therapy for bronchial asthma, atopic dermatitis, etc.

New phenylpyridylpiperazine compounds

-

Page/Page column 15, (2008/06/13)

A compound selected from those of formula (I): [image] wherein: X represents a C(O) or SO2 group, R1 represents an aryl group or a group NR3R4 wherein R3 and R4 are as defined in the description, R2 represents an alkyl, (C3-C8)cycloalkyl or (C3-C8)cycloalkyl-(C1-C6)alkyl group, its isomers, and addition salts thereof, and medicinal products containing the same which are useful in treating conditions treatable by antagonists of type H3 central histamine receptors.

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