- Versatile Route to Substituted Ketones through Charge-Directed Conjugate Addition Reactions
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Charge-directed conjugate addition reactions have been applied to the preparation of highly substituted ketones.Acylphosphoranes resulting from conjugate addition-alkylation reactions are reduced by Al-Hg to β-keto esters, which, upon alkylation and hydrolysis, give ketones in high yields.An application of this methodology to the synthesis of 9, the defense substance of L. longipes, is described.
- Cooke, Manning P.
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p. 4963 - 4968
(2007/10/02)
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