Synthesis of β-lactam antibiotics by the sulfeno-cycloamination
A novel efficient beta -lactam synthesis was achieved by two successive processes (sulfeno-cycloamination), addition of phenysulfenyl chloride to alpha , beta -unsaturated amides followed by base treatment. Key synthetic intermediates of monobactams and nocardicin derivatives were obtained via this method. construction of the 1-carbapenam ring system by the sulfenocycloamination is also described.
Ihara,Haga,Yonekura,et al.
p. 7345 - 7352
(2007/10/02)
NOVEL STEREOSELECTIVE SYNTHESIS OF β-LACTAMS VIA EPISULFONIUM ION INTERMEDIATE
A number of monocyclic β-lactams were synthesized by addition of benzenesulfonyl chloride to α,β-unsaturated olefins followed by base treatment in the presence of a phase transfer catelyst.The cyclization proceeds in a stereoselective manner most probably
Ihara, Masataka,Fukumoto, Keiichiro
p. 1435 - 1438
(2007/10/02)
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