- Hydrosilylation of RN=CH Imino-Substituted Pyridines without a Catalyst
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Treatment of the neutral pyridine-based ligands L1–L3, bearing either one or two RN=CH imine moieties {where L1 and L2 are N,N-chelating ligands 2-(RN=CH)C5H4N (R=Ph (L1) or R=2,4,6-Ph3C6H2 (L2)) and L3 is the N,N,N-chelating ligand 2,6-(RN=CH)2C5H3N (R=2,6-iPr2C6H3)}, with HSiCl3 yielded N→Si-coordinated silicon(IV) amides 2-{Cl3SiN(R)CH2}C5H4N (1, R=Ph; 2, R=2,4,6-Ph3C6H2) and 2-{Cl3SiN(R)CH2}-6-(RN=CH)C5H4N (3, R=2,6-iPr2C6H3). The organosilicon amides 1–3 are the products of spontaneous hydrosilylation of the RN=CH imine moiety induced by N→Si coordination of the proposed N,N-chelated chlorosilanes L1→SiHCl3 (1 a), L2→SiHCl3 (2 a), and L3→SiHCl3 (3 a). Furthermore, the reaction of L3 with an excess of HSiCl3 provided the intramolecularly coordinated chlorosilicon diamide cyclo-{(C5H3N)-1,3-(CH2NR)2}SiCl2 (4) (R=2,6-iPr2C6H3) as the product of spontaneous reduction of both RN=CH imine moieties. The compounds have been characterized by NMR spectroscopy (1–4) and single-crystal X-ray diffraction analysis (1, 3, and 4). The mechanism of the hydrosilylation of the second RN=CH imine moiety in 3 by an excess of SiHCl3 has also been studied. The experimental work is supplemented by DFT calculations.
- Novák, Miroslav,Ho?nová, Hana,Dostál, Libor,Glowacki, Britta,Jurkschat, Klaus,Ly?ka, Antonín,Ruzickova, Zdenka,Jambor, Roman
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supporting information
p. 3074 - 3083
(2017/03/13)
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- NOVEL AMIDINE COMPOUNDS FOR TREATING MICROBIAL INFECTIONS
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Novel amidine and diamidine compounds are useful in the treatment of microbial infections, including mycobacterial, fungal and protozoal infections. Pharmaceutical formulations comprising these compounds can be used in methods of treating microbial infect
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(2010/02/11)
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