- Synthesis method of 2-(4-ethoxyphenyl)-2-methyl propanol
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The invention discloses a synthetic method of 2-(4-ethoxyphenyl)-2-methyl propanol, and belongs to the technical field of organic synthesis. The method comprises the following steps: performing isobutyryl chloride Friedel-Crafts acylation by taking cheap phenethyl ether as a raw material and ionic liquid as a reaction solvent, extracting and separating methyl tert-butyl ether after reaction, washing and drying an ether phase, recovering the ether phase, distilling and purifying to obtain a product, adding tert-butyl ether, adding metered liquid bromine for bromination, washing after bromination, treating and crystallizing, adding petroleum ether, refluxing, dehydrating and condensing with neopentyl glycol under the catalytic action of p-toluenesulfonic acid to obtain a condensation compound; and carrying out high-temperature transposition on the condensation compound and a catalyst zinc salt in a solvent, directly hydrolyzing with an alkaline solution, and finally reducing under the action of sodium borohydride and aluminum trichloride to obtain the 2-(4-ethoxyphenyl)-2-methyl propanol. The method is high in yield, safe, environmentally friendly and easy to operate, a small amount of aluminum trichloride is supplemented into the ionic liquid and then reused, and neopentyl glycol regenerated through the hydrolysis reaction can also be recycled.
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Paragraph 0031
(2021/05/01)
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- Method for manufacturing Etofenprox intermediate
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The present invention relates to a method for efficiently manufacturing 2-(4-ethoxyphenyl)-2-methylpropan-1-ol, which is an etofenprox intermediate. More specifically, the present invention relates to the method for manufacturing the etofenprox intermediate which can more easily increase a yield than an existing process and can be usefully used in the development of etofenprox.COPYRIGHT KIPO 2020
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Paragraph 0062-0065
(2019/12/25)
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- Preparation method of 2-(4-ethoxyphenyl)-2.2-dimethylethanol
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The invention discloses a preparation method of 2-(4-ethoxyphenyl)-2.2-dimethylethanol. The preparation method comprises the following preparation steps: (1) dissolving one mole of acid in an alcoholsolvent, or in a mixed solvent consisting of the alcohol solvent and an ethers solvent; (2) heating the mixed solvent in step (1); and adding borohydride and metal salt; (3) continuing carrying out heat-insulation reaction, and recycling the alcohol solvent or the alcohol solvent or the ethers solvent under reduced pressure; and adding an organic solvent, dropwise adding hydrochloric acid while stirring to react, adding the organic solvent again, standing, layering and extracting; and drying an organic phase by using anhydrous sodium sulfate, and concentrating under reduced pressure to obtainthe product. Compared with the prior art, the method is high in safety, and the process is reasonable, simple and conveniently; and raw materials are easily obtained. The cost of the product is low, the quality is high, and the preparation method is environmentally friendly, and is suitable for industrial production; and the total yield of reaction taking 2-(4-ethoxyphenyl)-2.2-dimethylacetic acidcan reach 95% or above, and the content of the product reaches 98%.
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Paragraph 0035; 0036; 0037; 0039; 0040; 0041; 0042-0057
(2018/09/11)
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