- Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux
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The multidrug resistance protein 1 (MRP1) is involved in multidrug resistance of cancer cells by mediating drug efflux out of cells, often in co-transport with glutathione (GSH). GSH efflux mediated by MRP1 can be stimulated by verapamil. In cells overexp
- Lorendeau, Doriane,Dury, Lauriane,Genoux-Bastide, Estelle,Lecerf-Schmidt, Florine,Sim?es-Pires, Claudia,Carrupt, Pierre-Alain,Terreux, Rapha?l,Magnard, Sandrine,Di Pietro, Attilio,Boumendjel, Ahcène,Baubichon-Cortay, Hélène
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p. 235 - 245
(2014/07/21)
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- Synthesis and preliminary biological evaluation of chrysin derivatives as potential anticancer drugs
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A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6-trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.
- Zheng, Xing,Zhao, Fei Fei,Liu, Yun Mei,Yao, Xu,Zheng, Zi Tong,Luo, Xing,Liao, Duan Fang
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scheme or table
p. 6 - 8
(2011/10/31)
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- Efficient synthesis of nitroflavones by cyclodehydrogenation of 2prime;-hydroxychalcones and by the Baker-Venkataraman method
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Several nitroflavone derivatives were synthesized by cyclodehydrogenation of 2′-hydroxychalcones and by the Baker-Venkataraman approach, starting from 2′-hydroxyacetophenones and benzoic acid derivatives. Nitroflavones synthesised by the first synthetic a
- Barros, Ana I. R. N. A.,Silva, Artur M. S.
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p. 1505 - 1528
(2007/10/03)
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- Silica gel supported InBr3 and InCl3: New catalysts for the facile and rapid oxidation of 2′-hydroxychalcones and flavanones to their corresponding flavones under solvent free conditions
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Silica gel supported InBr3 or InCl3 (15-20 mol %) were explored as a new solid-support catalysts for the facile and efficient oxidation, under solvent free conditions, of 2′-hydroxychalcones and flavanones to yield the corresponding flavones in >80% yield. The catalysts are easily prepared, stable, and efficient under mild reaction conditions.
- Ahmed, Naseem,Ali, Hasrat,Van Lier, Johan E.
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p. 253 - 256
(2007/10/03)
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