- SUBSTITUTED OXOPYRIDINE DERIVATIVES
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The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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Paragraph 0511-0514
(2018/05/24)
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- Protonation of Some 3-, 4-, and 5-Substituted Thiophen-2-carboxamides
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The protonation behaviour at 25 deg C in aqueous sulphuric acid solution of some 3-, 4-, and 5-substituted thiophen-2-carboxamides has been investigated by u.v. spectrophotometry. pKBH+ Values were calculated by HA and Bunnett-Olsen methods using the multivariate analysis.A positive ?α-s value was obtained indicating that the sulphur atom acts as an electron-withdrawing substituent.Plots of pKBH+of 4- and 5-substituted thiophen-2-carboxamides and 3-substituted derivatives against ? were linear with the slope +1.10 and +1.28, respectively.A ρo/ρm,p ratio higher than unity (1.16) has been observed indicating a larger transmission of electronic effects between the 2- and 3-positions of the thiophen ring than between the 2- and 4- or 5-positions.
- Alberghina, Gaetano,Fisichella, Salvatore,Occhipinti, Salvatore,Consiglio, Giovanni,Spinelli, Domenico,Noto, Renato
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p. 1223 - 1226
(2007/10/02)
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