- 3,3-Diarylphthalides. Part I. Friedlaender reaction of 3′-alkylphenolphthaleins
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Friedlaender reaction was investigated, starting from 3′-alkyl-derivatives of phenolphthalein 1-3 (alkyl = Me, Et and i-Pr) and hydroxylamine in strongly alkaline medium. The process was found to give, after acidic hydrolysis of primarily formed anil-type semi-products, a mixture of two 2-aroylbenzoic acids (2-ABAs) in each case. Identification and quantification of 2-ABAs were carried out within RP-HPLC on ODS column. Based on quantitative results, migratory aptitude (MA) parameter values of ionized 4-hydroxy-3-alkylphenyl nuclei were calculated, taking an unsubstituted ionized 4-hydroxyphenyl ring as a standard.
- Ruminski
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p. 908 - 914
(2007/10/03)
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- Syntheses and Reactivity of 2-Aroylbenzoic Acids, II. 2-(4-Hydroxy-3-isopropylbenzoyl)benzoic Acid
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Die Friedel-Crafts-Acylierung von 2-Isopropylphenol mit Phthalsaeureanhydrid liefert nur die 2-(4-Hydroxy-3-isopropylbenzoyl)benzoesaeure (1) vom p-Acylphenol-Typ.Die Reaktionsfaehigkeit der Saeure 1 wurde untersucht, und ihre Derivate 2 - 10 werden besch
- Ruminski, Jan K.,Przewoska, Krystyna D.
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p. 3436 - 3443
(2007/10/02)
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