- Facile and selective deprotection of PMB ethers and esters using oxalyl chloride
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Oxalyl chloride, (0.5 equiv) was found to cleave the PMB group from alkyl, aryl PMB ethers, and esters to give corresponding alcohol and acid in good yields. This method offers simple and efficient protocol for the selective deprotection of PMB ether and ester in DCE at ambient temperature.
- Ilangovan, Andivelu,Anandhan, Karnambaram,Kaushik, Mahabir Prasad
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p. 1081 - 1084
(2015/02/19)
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- A convenient approach for the deprotection and scavenging of the PMB group using POCl3
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A convenient and high yielding approach for the deprotection and scavenging of the p-methoxybenzyl (PMB) group in PMB ethers and PMB esters was developed using POCl3 as the reagent. 4-Methoxybenzyl chloride, a starting material used for the preparation of PMB ethers and esters was regenerated in the deprotection step. This mild and selective procedure tolerates several acid sensitive functional groups. The Royal Society of Chemistry 2013.
- Ilangovan, Andivelu,Saravanakumar, Shanmugasundar,Malayappasamy, Subramani,Manickam, Govindaswamy
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p. 14814 - 14828
(2013/09/02)
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- Lead optimization of 3-carboxyl-4(1 H)-quinolones to deliver orally bioavailable antimalarials
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Malaria is a protozoal parasitic disease that is widespread in tropical and subtropical regions of Africa, Asia, and the Americas and causes more than 800,000 deaths per year. The continuing emergence of multidrug-resistant Plasmodium falciparum drives the ongoing need for the development of new and effective antimalarial drugs. Our previous work has explored the preliminary structural optimization of 4(1H)-quinolone ester derivatives, a new series of antimalarials related to the endochins. Herein, we report the lead optimization of 4(1H)-quinolones with a focus on improving both antimalarial potency and bioavailability. These studies led to the development of orally efficacious antimalarials including quinolone analogue 20g, a promising candidate for further optimization.
- Zhang, Yiqun,Clark, Julie A.,Connelly, Michele C.,Zhu, Fangyi,Min, Jaeki,Guiguemde, W. Armand,Pradhan, Anupam,Iyer, Lalitha,Furimsky, Anna,Gow, Jason,Parman, Toufan,El Mazouni, Farah,Phillips, Margaret A.,Kyle, Dennis E.,Mirsalis, Jon,Guy, R. Kiplin
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scheme or table
p. 4205 - 4219
(2012/07/02)
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- 4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS
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The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.
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Page/Page column 55-56
(2010/02/13)
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- Syntheses of 3-Chloro-5,8-disubstituted-6,7 or 8-monosubstituted-2-(substituted phenoxy or quinolinoxy)-methyl-4-substituted-anilinoquinolines as Possible Antimalarial Agents
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3-Chloro-2-(substituted-phenoxy)methyl-6-methoxy or 7-methyl-4-substituted-anilino-quinolines (19-24), 3-carbethoxy-4-hydroxy-5 or 7-quinolines (26, 27) and 2,4
- Bhat, Balkrishen,Roy, Jalpana,Seth, M.,Bhaduri, A. P.
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p. 444 - 448
(2007/10/02)
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