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84243-58-3

Articles about 84243-58-3Total 5 be found

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Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
Substituted 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinone compounds and 6-(substituted)phenyl-3(2H)-pyridazinone compounds and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents. Said compounds cause a significant increase in myocardial contractility in the dog. Said compounds also cause a decrease in blood pressure in the spontaneously hypertensive rat. Said compounds are produced by reacting substituted γ-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinones which are dehydrogenated to 6-(substituted)phenyl-3(2H)-pyridazinones. Both the intermediate 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinones and the 6-(substituted)phenyl-3(2H)-pyridazinones are useful as cardiotonic and antihypertensive agents.
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(2008/06/13)

Method of treating heart failure and medicaments therefor
The present invention relates to a combination of selected cardiotonic agents with selected adenosine receptor agonist antihypertensive agents resulting in a synergistic increase in myocardial contractility and cardiac output thereby rendering such combin
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(2008/06/13)

Cardiotonic Agents. 2. Synthesis and Structure-Activity Relationships of 4,5-Dihydro-6--3(2H)-pyridazinones: A New Class of Positive Inotropic Agents
A series of 4,5-dihydro-6--3(2H)-pyridazinones and related compounds were synthesized and evaluated for positive inotropic activity.Most members of this series produced dose-related increases in myocardial contractility that we
Sircar, Ila,Duell, Bradley L.,Bobowski, George,Bristol, James A.,Evans, Dale B.
p. 1405 - 1413
(2007/10/02)

Cardiotonic Agents. 1. 4,5-Dihydro-6--3(2H)-pyridazinones: Novel Positive Inotropic Agents for the Treatment of Congestive Heart Failure
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Bristol, James A.,Sircar, Ila,Moos, Walter H.,Evans, Dale B.,Weishaar, Ronald E.
p. 1099 - 1101
(2007/10/02)

Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)-phenyl]-3(2H)-pyridazinone compounds and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone compounds and pharmaceutically acceptable salts thereof are useful as cardiotonic agents. Said compounds cause a sig
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(2008/06/13)

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Chemical Properties

Melting Point: 218℃
Density: 1.34g/cm³
Solubility:DMSO: 50 mg/mL, clear, yellow
Storage Temp.:Sealed in dry,Room Temperature
Refractive Index: 1.696
PSA: 59.28000
LogP: 1.25080

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