cas 84254-97-7, N-BENZYL-4-CYANO-4-(1-PIPERIDINO)-PIPERIDINE, 98 | Articles data ｜lookchem

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84254-97-7

Articles about 84254-97-7Total 4 be found

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Dual NK2/NK3-antagonists, pharmaceutical compositions comprising them, and processes for their preparation
Dual NK2/NK3-antagonists corresponding to formula I: and physiologically compatible salts of such compounds in which X and R1 to R5 have specific defined meanings, pharmaceutical compositions containing such compounds, methods of using such compounds to treat or inhibit disorders mediated by tachykinin receptors, and a process for preparing such compounds.
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Page/Page column 27

(2010/11/28)

Novel piperidinecarboxamide derivatives, method for preparing same and pharmaceutical compositions containing same
The invention relates to compounds of formula: as well as their salts with inorganic or organic acids, their solvates and/or their hydrates, which exhibit a very high affinity both for the human NK2 receptors for neurokinin A and for the human NK3 receptors for neurokinin B and are antagonists of the said receptors. The invention also relates to their method of preparation, the pharmaceutical compositions containing them and their use for the preparation of medicaments.
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Page/Page column 4; 12

(2010/02/08)

SUBSTITUTED HETEROCYCLIC COMPOUNDS METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT
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(2008/06/13)

Nitrogen analogues of phencyclidine: 1-Alkyl-4-phenyl-4-(1-piperidinyl)piperidines
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Iorio,Molinari,Scotti de Carolis,Niglio
p. 599 - 611
(2007/10/02)

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Chemical Properties

Melting Point: 103-106°C
Boiling Point: 415.96°C (rough estimate)
Flash Point:175.2oC
Density: 0.9805 (rough estimate)
Solubility:Chloroform (Slightly), Methanol (Slightly)
Storage Temp.:2-8°C
Vapor Pressure: 0-0Pa at 20-25℃
Refractive Index: 1.5480 (estimate)
PKA: 6.70±0.10(Predicted)
PSA: 30.27000
LogP: 2.90648

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