- 4-HYDROXY-2-QUINOLONES 19. A NEW SYNTHESIS OF 3-ALKYL-2-OXO-4-HYDROXYQUINOLINES
-
3-Alkyl-subtituted 2-oxo-4-hydroxyquinolines were obtained in high yields from N,N'-di-2-alkoxycarbonylanilides of alkylmalonic acids under conditions of the Dieckmann condensation.Some types of biological activity were found for the compounds synthesized.
- Ukrainets, I. V.,Taran, S. G.,Evtifeeva, O. A.,Gorokhova, O. V.,Bezuglyi, P. A.,et al.
-
p. 591 - 595
(2007/10/02)
-
- Synthesis of 3-Heptyl- and 3-Nonyl-2,4(1H,3H)-quinolinediones
-
3-Alkyl-3-hydroxy-2,4(1H,3H)-quinolinediones 4, which are metabolites of some Pseudomonas species, were synthesized by oxidation of the corresponding 4-hydroxy-2(1H)-quinolones 3.By halogenation of 3 the 3-chloro- and 3-bromo-2,4(1H,3H)-quinolinediones 5 and 7, respectively, are obtained.Exchange of the chloro substituent in 5 with sodium azide yields the 3-azido derivative 8, while reaction with potassium fluoride affords the 3-fluoroquinolinedione 6.
- Laschober, Rita,Stadlbauer, Wolfgang
-
p. 1083 - 1086
(2007/10/02)
-