84440-19-7

Basic information

• Product Name: 1H-1,2,3-TRIAZOLE-4-METHANOL
• Synonyms: 1H-1,2,3-TRIAZOLE-4-METHANOL;1H-1,2,3-Triazole-5-Methanol;(1H-1,2,3-Triazol-4-yl)Methanol;(2H-1,2,3-triazol-4-yl)methanol;2H-1,2,3-triazol-4-ylmethanol;2H-triazol-4-ylmethanol
• CAS NO: 84440-19-7
• Molecular Formula: C3H5N3O
• Molecular Weight: 99.09
• Mol File: 84440-19-7.mol

Chemical Properties

• Boiling Point: 346.5°C at 760 mmHg
• Flash Point: 163.4°C
• Appearance: /
• Density: 1.456g/cm³
• Vapor Pressure: 2.17E-05mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-1,2,3-TRIAZOLE-4-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,3-TRIAZOLE-4-METHANOL(84440-19-7)
• EPA Substance Registry System: 1H-1,2,3-TRIAZOLE-4-METHANOL(84440-19-7)

Safety Data

• Hazardous Substances Data: 84440-19-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-1,2,3-Triazole-4-methanol is used as an intermediate in the synthesis of various pharmaceuticals, particularly antiviral and anticancer drugs. Its unique chemical structure allows for the development of novel therapeutic agents with improved efficacy and reduced side effects.
Used in Petroleum Industry:
1H-1,2,3-Triazole-4-methanol is used as a corrosion inhibitor in the petroleum industry. Its ability to form protective films on metal surfaces helps prevent corrosion, thereby extending the lifespan of equipment and reducing maintenance costs.
Used in Coordination Chemistry:
1H-1,2,3-Triazole-4-methanol is used as a ligand in coordination chemistry. Its versatile coordination properties enable the formation of stable complexes with various metal ions, which can be utilized in catalysis, sensing, and other applications.
Used in Antimicrobial Applications:
1H-1,2,3-Triazole-4-methanol has been studied for its potential antimicrobial and antifungal properties. Its ability to disrupt microbial cell membranes and inhibit essential cellular processes makes it a promising candidate for the development of new antimicrobial agents to combat drug-resistant infections.

InChI:InChI=1/C3H5N3O/c7-2-3-1-4-6-5-3/h1,7H,2H2,(H,4,5,6)

Upstream product

• 14989-89-0 3-azido-1-propyne 
• 118724-05-3 (1H-[1,2,3]triazol-4-yl)methanamine 
• 107-19-7 propargyl alcohol 
• 123-91-1 1,4-dioxane 
• 4648-54-8 trimethylsilylazide 

Relevant articles and documents

SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

Investigation of copper-free alkyne/azide 1,3-dipolar cycloadditions using microwave irradiation

The prevalence of 1,3-dipolar cycloadditions of azides and alkynes within both biology and chemistry highlights the utility of these reactions. However, the use of a copper catalyst can be prohibitive to some applications. Consequently, we have optimized

SUBSTITUTED NITROGEN CONTAINING COMPOUNDS

Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

Synthesis of N-unsubstituted 1,2,3-triazoles via a cascade including propargyl azides, allenyl azides, and triazafulvenes

About thirty NH-1,2,3-triazoles with at least one additional functional group in a side chain at C-4 were prepared from propargyl substrates. These reactions included propargyl azides and their [3,3]-sigmatropic rearrangement to generate short-lived allenyl azides, which cyclized to form triazafulvenes that could be trapped by addition of N- or O-nucleophiles. In most cases, simple substrates and cheap sodium azide were utilized as starting compounds, and the syntheses were performed by using a one-pot procedure without isolation of any dangerous azides. This method to prepare NH-1,2,3-triazoles turned out to be compatible with quite different substitution patterns of the propargyl substrate.

MONOBACTAM ORGANIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS

This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.

Water-soluble NHC-Cu catalysts: Applications in click chemistry, bioconjugation and mechanistic analysis

Copper(i)-catalyzed 1,3-dipolar cycloaddition of azides and terminal alkynes (CuAAC), better known as "click" reaction, has triggered the use of 1,2,3-triazoles in bioconjugation, drug discovery, materials science and combinatorial chemistry. Here we report a new series of water-soluble catalysts based on N-heterocyclic carbene (NHC)-Cu complexes which are additionally functionalized with a sulfonate group. The complexes show superior activity towards CuAAC reactions and display a high versatility, enabling the production of triazoles with different substitution patterns. Additionally, successful application of these complexes in bioconjugation using unprotected peptides acting as DNA binding domains was achieved for the first time. Mechanistic insight into the reaction mechanism is obtained by means of state-of-the-art first principles calculations.

Optimizing the control of apoptosis by amide/triazole isosteric substitution in a constrained peptoid

Apoptosis is a biological process relevant to several human diseases that is strongly regulated through protein-protein complex formation. We have previously reported a peptidomimetic compound as potent apoptotic modulator. Structural studies of this comp

15N NMR spectroscopic and theoretical GIAO-DFT studies for the unambiguous characterization of disubstituted 1,2,3-triazoles

The 1,2,3-triazole ring has recently attracted a renewed interest as a structural scaffold with many applications in different fields. However, very often, the unambiguous assignment of the correct structure is not an easy task, and the development of rob

SYNTHESIS AND USE OF THERAPEUTIC METAL ION CONTAINING POLYMERIC PARTICLES

Therapeutic particles contain metal ions and are characterized by the use of unique ligand sets capable of making the metal ion complex soluble in biological media to induce selective toxicity in diseased cells. The particles may comprise a polymeric base particle, at least one pharmaceutically active metal ion, including metal ions from more than one metal element, a ligand that is covalently attached to the polymeric base particle and attached to the metal ion via a stimuli-responsive bond, and a cell targeting component. When the metal ion-containing particle enters a pre-defined environment, the ligands binding the metal to the particle are broken, triggering release of the free metal ion while the original ligands remain covalently bound to the particle.

METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)

Provided herein are methods of treating cancer comprising administering a topoisomerase inhibitor, temozolomide, or a platin in combination with a Compound of Formula (I) or Formula (II), where the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein.