844439-52-7

Basic information

• Product Name: (R)-β-N-acetyl-p-chloro-phenylalanine methyl ester
• Synonyms: (R)-β-N-acetyl-p-chloro-phenylalanine methyl ester;(betaR)-beta-(Acetylamino)-4-chlorobenzenepropanoic acid ethyl ester
• CAS NO: 844439-52-7
• Molecular Formula: C13H16ClNO3
• Molecular Weight: 269.72404
• Mol File: 844439-52-7.mol

Chemical Properties

• Appearance: /
• Density: 1.188
• CAS DataBase Reference: (R)-β-N-acetyl-p-chloro-phenylalanine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-β-N-acetyl-p-chloro-phenylalanine methyl ester(844439-52-7)
• EPA Substance Registry System: (R)-β-N-acetyl-p-chloro-phenylalanine methyl ester(844439-52-7)

Safety Data

• Hazardous Substances Data: 844439-52-7(Hazardous Substances Data)

Usage

Uses

Used in Research and Studies:
(R)-β-N-acetyl-p-chloro-phenylalanine methyl ester is utilized as a research compound for investigating amino acid metabolism, providing insights into the biochemical processes and pathways involving phenylalanine and its derivatives.
Used in Pharmaceutical Development:
(R)-β-N-acetyl-p-chloro-phenylalanine methyl ester serves as a key intermediate in the development of pharmaceuticals, potentially contributing to the creation of novel drugs that target specific molecular pathways related to various diseases and conditions.
Used in Enzyme Kinetics Studies:
(R)-β-N-acetyl-p-chloro-phenylalanine methyl ester is employed as a substrate or inhibitor in enzyme kinetics research, helping to elucidate the mechanisms of enzymes involved in the metabolism of phenylalanine and related compounds.
Potential Applications in Neurological and Psychiatric Disorders:
While further research is necessary, (R)-β-N-acetyl-p-chloro-phenylalanine methyl ester may have potential applications in the treatment of neurological and psychiatric disorders, given its involvement in amino acid metabolism and its interactions with enzyme systems.

Upstream product

• 434957-51-4 ethyl 3-acetamido-3-(4-chlorophenyl)-2-propenoate 

Relevant articles and documents

Chiral 1-phenylethylamine-derived phosphine-phosphoramidite ligands for highly enantioselective Rh-catalyzed hydrogenation of β-(acylamino) acrylates: Significant effect of substituents on 3,3′-positions of binaphthyl moiety

A series of new chiral phosphine-phosphoramidite ligands with a 3,3′-substituted binaphthyl moiety were prepared from 1-phenylethylamine, and successfully applied in the Rh-catalyzed asymmetric hydrogenation of β-(acylamino)acrylates. The research disclosed that the substituents on the 3,3′-positions of binaphthyl moiety significantly influenced the enantioselectivity.

Practical Rh(I)-catalyzed asymmetric hydrogenation of β-(acylamino) acrylates using a new unsymmetrical hybrid ferrocenylphosphine-phosphoramidite ligand: Crucial influence of an N-H proton in the ligand

(Chemical Equation Presented) Excellent enantioselectivities and high turnovers (S/C = 5000) were achieved in the Rh(I)-catalyzed asymmetric hydrogenation of both β-aryl-and β-alkyl-β-(acylamino)acrylates with a new unsymmetrical hybrid ferrocenylphosphine-phosphoramidite ligand, and the presence of an N-H proton in the ligand was demonstrated to have a crucial role in the enantioselectivity.

Highly effective chiral ortho-substituted BINAPO ligands (o-BINAPO): Applications in Ru-catalyzed asymmetric hydrogenations of β-aryl-substituted β-(acylamino)acrylates and β-keto esters

A novel family of chiral ortho-substituted BINAPO ligands (o-BINAPO) were synthesized from BINOL, and their Ru complexes were highly efficient catalysts for asymmetric hydrogenation of β-aryl-substituted β-(acylamino)acrylates and β-aryl-substituted β-keto esters. The Ru-bisphosphinite catalysts can tolerate an E/Z mixture of β-aryl-substituted β-(acylamino)acrylates. These highly enantioselective hydrogenations provide a useful way to prepare β-aryl-substituted β-amino acids and β-hydroxyl acids. Copyright