Synthesis and Investigation of the Abiotic Formation of Pyonitrins A-D
Pyonitrins A-D are recently isolated natural products from the insect-associated Pseudomonas protegens strain, which were isolated from complex fractions that exhibited antifungal activity via an in vivo murine candidiasis assay. Genomic studies of Pseudomonas protegens suggested that pyonitrins A-D are formed via a spontaneous nonenzymatic reaction between biosynthetic intermediates of two well-known natural products pyochelin and pyrrolnitrin. Herein we have accomplished the first biomimetic total synthesis of pyonitrins A-D in three steps and studied the nonenzymatic formation of the pyonitrins using 15N NMR spectroscopy.
Aniebok, Victor,Lee, Hsiau-Wei,Macmillan, John B.,Shingare, Rahul D.
supporting information
(2020/02/22)
Selective reduction of halogenated nitroarenes with hydrazine hydrate in the presence of Pd/C
A large variety of halogenated nitroarenes have been selectively reduced with hydrazine hydrate in the presence of Pd/C to give the corresponding (halogenated) anilines in good yield.
Li, Fang,Frett, Brendan,Li, Hong-Yu
p. 1403 - 1408
(2014/06/23)
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