84539-07-1

Basic information

• Product Name: 3,5-DIBROMO-N,N-DIMETHYLPYRAZINAMINE
• Synonyms: 3,5-DIBROMO-N,N-DIMETHYLPYRAZINAMINE;2-Pyrazinamine,3,5-dibromo-N,N-dimethyl-;(3,5-Dibromo-pyrazin-2-yl)-dimethyl-amine
• CAS NO: 84539-07-1
• Molecular Formula: C₆H₇Br₂N₃
• Molecular Weight: 280.96
• Mol File: 84539-07-1.mol

Chemical Properties

• Boiling Point: 299.952°C at 760 mmHg
• Flash Point: 135.206°C
• Appearance: /
• Density: 1.921g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3,5-DIBROMO-N,N-DIMETHYLPYRAZINAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIBROMO-N,N-DIMETHYLPYRAZINAMINE(84539-07-1)
• EPA Substance Registry System: 3,5-DIBROMO-N,N-DIMETHYLPYRAZINAMINE(84539-07-1)

Safety Data

• Hazardous Substances Data: 84539-07-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,5-DIBROMO-N,N-DIMETHYLPYRAZINAMINE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 3,5-DIBROMO-N,N-DIMETHYLPYRAZINAMINE serves as an intermediate in the production of agrochemicals. Its properties contribute to the formulation of effective pesticides, herbicides, and other agricultural chemicals that enhance crop protection and yield.
Used in Organic Synthesis:
3,5-DIBROMO-N,N-DIMETHYLPYRAZINAMINE is used as a reactant in the creation of novel heterocyclic compounds and organic functional groups. Its versatility in organic synthesis allows for the development of new chemical entities with potential applications in various fields, including materials science, medicinal chemistry, and specialty chemicals.

InChI:InChI=1/C6H7Br2N3/c1-11(2)6-5(8)10-4(7)3-9-6/h3H,1-2H3

Upstream product

• 13134-49-1 3-(dimethylamino)pyrazine 1-oxide 
• 5214-29-9 2-Dimethylamino-pyrazin 
• 24241-18-7 2-amino-3,5-dibromopyrazine 
• 74-88-4 methyl iodide 
• 894808-28-7 3,5-dibromo-N-methylpyrazin-2-amine 

Downstream Products

• 894808-41-4 5-Bromo-N,N-dimethyl-3-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-amine 

Relevant articles and documents

2,3-Diaminopyrazines as rho kinase inhibitors

Inhibition of rho kinase (ROCK) has been recognized as an important target for a number of diseases, including glaucoma. Herein we report SAR development around two hits from a kinase library that led to the discovery of the ROCK inhibitor compound 38. In vitro and in vivo analysis of this compound, including its effects in a monkey model of glaucoma will be discussed.

PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS

Compounds of formula (I) selectively inhibitproduction of Aβ(1-42) and hence find use in treatment of Alzheimer's disease and other conditions associated with deposition ofA(β) in the brain.

Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases and conditions

Methods for using aminopyrazine analogs to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of aminopyrazine analogs, are also disclosed.

Synthesis and cytotoxicity evaluation of novel indolylpyrimidines and indolylpyrazines as potential antitumor agents

Novel indolylpyrimidines and indolylpyrazines have been synthesized as potential antitumor agents. They were screened in a panel of 60 human tumor cell lines in vitro. Compounds 7, 9, 10, 15, 21 exhibited efficiently cytotoxic activities with GI50 values in the low micromolar range against a variety of human cancer cell lines. 2,4-Bis(3′-indolyl)pyrimidine 8 displayed selective cytotoxic activity against IGROV1 tumor cell line with the GI50 value below 0.01 μM.

Bromination of Some Pyridine and Diazine N-Oxides

Selected monosubstituted pyridines, pyrazines, pyrimidines, and their N-oxides, having an electron-donating substituent, were successfully brominated under very mild conditions.The N-oxide function itself is not sufficient to cause these ?-deficient systems to undergo electrophilic aromatic halogenation.Only strongly electron-donating substituents (amino groups) activate the heterocyclic nucleus toward bromination.These substituents direct the electrophilic substitution ortho/para to them with or without the N-oxide group present.Pyridine and diazines with moderately activating substituents such as alkoxy groups are brominated only when their ortho/para activation is augmented by the activation of the N-oxide funtion.Failure to brominate 5-methoxypyrimidine 1-oxide may well reflect the greater ? deficiency of the pyrimidine ring.