84546-13-4

Upstream product

• 4546-25-2 6-bromo-2-methyl-3-phenylquinazolin-4(3H)-one 

Downstream Products

• 514830-21-8 6-bromo-2-hydrazinomethyl-3-phenyl-3H-quinazolin-4-one 
• 514830-35-4 3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-(6-bromo-4-oxo-3-phenyl-3,4-dihydro-quinazolin-2-ylmethyl)-hydrazide 
• 514830-37-6 3-(4-dimethylamino-phenyl)-acrylic acid N'-(6-bromo-4-oxo-3-phenyl-3,4-dihydro-quinazolin-2-ylmethyl)-hydrazide 
• 514830-38-7 3-(4-methoxy-phenyl)-acrylic acid N'-(6-bromo-4-oxo-3-phenyl-3,4-dihydro-quinazolin-2-ylmethyl)-hydrazide 
• 514830-36-5 3-phenyl-acrylic acid N'-(6-bromo-4-oxo-3-phenyl-3,4-dihydro-quinazolin-2-ylmethyl)-hydrazide 
• 514830-25-2 acetic acid N'-(6-bromo-4-oxo-3-phenyl-3,4-dihydro-quinazolin-2-ylmethyl)-hydrazide 

Relevant academic research and scientific papers

Synthesis and anti-inflammatory activity of some new 2,3-disubstituted-6-monosubstituted-quinazolin-4(3H)-ones

Some new quinazolinone derivatives, 3-(substituted phenyl)-2-(substituted phenylchalconylaminoazetidinon-2′-yl)-6-monosubstitutedquinazolin-4 (3H)-ones have been synthesized by the reaction of 3-(substituted phenyl)-2-(substituted phenylchalconylhydrazinomethyl)-6-monosubstituted-quinazolin-4(3H)-ones with acetyl chloride in the presence of triethylamine. All the compounds of this series have been evaluated for their anti-inflammatory activity against carrageenan induced oedema in albino rats. The activity of the most active member of this series i.e. 3-(o-methoxyphenyl)-2-(p-dimethylaminophenylchalconylaminoazetidinon- 2′-yl) quinazolin-4(3H)-one has been studied in detial and is compared with phenylbutazone. Interestingly this compound exhibits better anti-inflammatory activity and lower ulccrogenic liability than phenylbutazone and its toxicity is also quite low.