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845866-72-0

2-(4-BROMOBENZYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE, commonly known as Bremazocine, is a benzomorphan chemical compound with potent analgesic and sedative properties. It functions as a selective kappa opioid receptor agonist, binding to and activating the kappa opioid receptors in the brain and spinal cord to produce its therapeutic effects. Bremazocine has been the subject of research for its potential applications in various medical fields, including chronic pain management, addiction treatment, and mood disorders. Its ability to reduce the development of tolerance and dependence compared to traditional opioid drugs makes it a promising candidate for these applications.

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  • 845866-72-0 Structure

  • Basic information

    1. Product Name: 2-(4-BROMOBENZYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE
    2. Synonyms: (1S,4S)-2-(4-BROMOBENZYL)-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE;(1S,4S)-(+)-2-(4-BROMO-BENZYL)-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE 2CF3COOH;2-[(4-BROMOPHENYL)METHYL]-2,5-DIAZABICYCLO[2.2.1]HEPTANE;2-(4-BROMOBENZYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE
    3. CAS NO:845866-72-0
    4. Molecular Formula: C12H15BrN2
    5. Molecular Weight: 267.16
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 845866-72-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 347.7°C at 760 mmHg
    3. Flash Point: 164.1°C
    4. Appearance: /
    5. Density: 1.43g/cm3
    6. Vapor Pressure: 5.27E-05mmHg at 25°C
    7. Refractive Index: 1.611
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-(4-BROMOBENZYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(4-BROMOBENZYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE(845866-72-0)
    12. EPA Substance Registry System: 2-(4-BROMOBENZYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE(845866-72-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 845866-72-0(Hazardous Substances Data)

845866-72-0 Usage

Uses

Used in Pain Management:
Bremazocine is used as an analgesic agent for the management of chronic pain. Its action on the kappa opioid receptors helps alleviate pain without causing the same level of tolerance and dependence associated with other opioid drugs, making it a safer alternative for long-term pain relief.
Used in Addiction Treatment:
In the field of addiction treatment, Bremazocine is used as a therapeutic agent to help manage withdrawal symptoms and reduce cravings associated with substance abuse. Its ability to modulate the kappa opioid receptors may provide relief from the discomfort and psychological distress experienced during the detoxification process.
Used in Mood Disorders:
Bremazocine is also being studied for its potential use in the treatment of mood disorders, such as depression and anxiety. Its interaction with the kappa opioid receptors may help regulate mood and emotional responses, providing relief from the symptoms of these conditions.
Used in Alcohol Withdrawal Treatment:
In the treatment of alcohol withdrawal symptoms, Bremazocine is used as a supportive therapy to alleviate the discomfort and distress associated with alcohol cessation. Its analgesic and sedative properties, along with its potential to reduce cravings, make it a valuable tool in managing the challenges of alcohol withdrawal.

Check Digit Verification of cas no

The CAS Registry Mumber 845866-72-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,5,8,6 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 845866-72:
(8*8)+(7*4)+(6*5)+(5*8)+(4*6)+(3*6)+(2*7)+(1*2)=220
220 % 10 = 0
So 845866-72-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H15BrN2/c13-10-3-1-9(2-4-10)7-15-8-11-5-12(15)6-14-11/h1-4,11-12,14H,5-8H2

845866-72-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(4-bromophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:845866-72-0 SDS

845866-72-0Downstream Products

845866-72-0Relevant articles and documents

Synthesis and in Vivo Evaluation of [123I]Melanin-Targeted Agents

Roberts, Maxine P.,Nguyen, Vu,Ashford, Mark E.,Berghofer, Paula,Wyatt, Naomi A.,Krause-Heuer, Anwen M.,Pham, Tien Q.,Taylor, Stephen R.,Hogan, Leena,Jiang, Cathy D.,Fraser, Benjamin H.,Lengkeek, Nigel A.,Matesic, Lidia,Gregoire, Marie-Claude,Denoyer, Delphine,Hicks, Rodney J.,Katsifis, Andrew,Greguric, Ivan

, p. 6214 - 6224 (2015)

This study reports the synthesis, [123I]radiolabeling, and biological profile of a new series of iodinated compounds for potential translation to the corresponding [131I]radiolabeled compounds for radionuclide therapy of melanoma. Ra

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