Demethylation of methoxypyridines with sodium trimethylsilanethiolate
Demethylation of methoxypyridines was accomplished in 55-87percent yield by use of ca. 1.5-2.5 equivalents of NaSSiMe3 in 1,3-dimethyl-2-imidazolidinone at 120-180 deg C.This method was found applicable to a methoxyquinoline and methoxypyridines containing a second substituent, such as Cl, OMe, and COOMe.
Shiao, Min-Jen,Ku, Wei-Shen,Hwu, Jih Ru
p. 323 - 328
(2007/10/02)
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