Hiyama cross-coupling of chloro-, fluoro-, and methoxypyridyltrimethylsilanes: Room-temperature novel access to functional bi(het)aryl
(Chemical Equation Presented) The incorporation of chloro, fluoro, or methoxy substituents on the pyridine ring of pyridyltrimethylsilanes allowed us to perform efficient Hiyama cross-coupling with various (het)aryl halides. The reactions proceeded smoothly at room temperature leading to the corresponding functional bis(het)aryl in fair to excellent yields. The presence of pyridine nitrogen α to the trimethylsilyl group was requisite to achieve the cross-coupling.
Pierrat, Philippe,Gros, Philippe,Fort, Yves
p. 697 - 700
(2007/10/03)
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